Neuronal activity regulates hippocampal miRNA expression
Neuronal activity regulates a broad range of processes in the hippocampus, including the
precise regulation of translation. Disruptions in proper translational control in the nervous …
precise regulation of translation. Disruptions in proper translational control in the nervous …
Evidence for altered hippocampal function in a mouse model of the human 22q11. 2 microdeletion
LJ Drew, KL Stark, K Fénelon, M Karayiorgou… - Molecular and Cellular …, 2011 - Elsevier
22q11. 2 chromosomal deletions are recurrent copy number mutations that increase the risk
of schizophrenia around thirty-fold. Deletion of the orthologous chromosomal region in mice …
of schizophrenia around thirty-fold. Deletion of the orthologous chromosomal region in mice …
Transgenic mice overexpressing the extracellular domain of NCAM are impaired in working memory and cortical plasticity
LH Brennaman, G Kochlamazashvili, L Stoenica… - Neurobiology of …, 2011 - Elsevier
The neural cell adhesion molecule, NCAM, is a pivotal regulator of neural development, with
key roles in axonal and dendritic growth and synaptic plasticity. Alterations in NCAM …
key roles in axonal and dendritic growth and synaptic plasticity. Alterations in NCAM …
Behavioral and molecular biomarkers in translational animal models for neuropsychiatric disorders
Z Sarnyai, M Alsaif, S Bahn, A Ernst, PC Guest… - International review of …, 2011 - Elsevier
Modeling neuropsychiatric disorders in animals poses a significant challenge due to the
subjective nature of diverse often overlapping symptoms, lack of objective biomarkers and …
subjective nature of diverse often overlapping symptoms, lack of objective biomarkers and …
A Drosophila genetic screen yields allelic series of core microRNA biogenesis factors and reveals post-developmental roles for microRNAs
Canonical animal microRNAs (miRNAs) are∼ 22-nt regulatory RNAs generated by stepwise
cleavage of primary hairpin transcripts by the Drosha and Dicer RNase III enzymes. We …
cleavage of primary hairpin transcripts by the Drosha and Dicer RNase III enzymes. We …
Annual Research Review: Transgenic mouse models of childhood‐onset psychiatric disorders
HR Robertson, G Feng - Journal of Child Psychology and …, 2011 - Wiley Online Library
Childhood‐onset psychiatric disorders, such as attention deficit hyperactivity disorder
(ADHD), autism spectrum disorder (ASD), mood disorders, obsessive compulsive spectrum …
(ADHD), autism spectrum disorder (ASD), mood disorders, obsessive compulsive spectrum …
Molecular mechanisms in 22q11 deletion syndrome
NM Williams - Schizophrenia bulletin, 2011 - academic.oup.com
It is now well recognized that as well as having a characteristic facial dysmorphology and a
range of congenital abnormalities, individuals with chromosome 22q11 deletion syndrome …
range of congenital abnormalities, individuals with chromosome 22q11 deletion syndrome …
The 3q29 microdeletion syndrome: report of three new unrelated patients and in silico “RNA binding” analysis of the 3q29 region
MJ Dasouki, GH Lushington, K Hovanes… - American Journal of …, 2011 - Wiley Online Library
The human 3q29 microdeletion syndrome is associated with mild facial dysmorphism,
developmental delay and variable congenital malformations. We report three new unrelated …
developmental delay and variable congenital malformations. We report three new unrelated …
From molecules to behavior: lessons from the study of rare genetic disorders
PL Roubertoux, PJ de Vries - Behavior genetics, 2011 - Springer
Rare diseases are defined as conditions with a prevalence of less than 1/2,000. To date
between 6,000 and 7,000 rare diseases have been identified and many of those have …
between 6,000 and 7,000 rare diseases have been identified and many of those have …