Schizophrenia is one of the most disabling psychiatric conditions. Current treatments target
monoamine receptors but this approach does not address the full complexity of the disorder …

Schizophrenia is a heritable disorder that may involve several common genes of small effect
and/or rare copy number variation, with phenotypic heterogeneity across patients …

Schizophrenia is a debilitating psychiatric disorder affecting 1% of the world's population.
The diagnostic criteria (DSM IV) are broad and characterized by positive and negative …

MicroRNAs are short 21-to 24-nucleotide (nt) RNA species that act as key regulators of gene
expression. Known primarily to modulate mRNA translation through recognition of specific …

Accumulating evidence indicates that the genetic architecture of psychiatric disorders does
not strictly conform to the common disease/common allele hypothesis. The contribution of …

Numerous miRNAs play an important role in translation regulation, modulating embryo
development, stem cells proliferation, and tissue differentiation. Aberrant miRNA expression …

I have prepared this dissertation in accordance with the guidelines set forth by the
Neuroscience Graduate Program in the School of Medicine, Oregon Health and Science …

Psychiatric disorders, like other common diseases, are multifactorial in nature and have
complex ge ne tic etiologies. The ge ne tic architecture underlying disease susceptibility is …

Das hochkonservierte Protein TDP-43 (transactivation response DNA binding proteín 43)
spielt im Mechanismus der Neurodegenerationen FTLD und ALS eine entscheidende Rolle …

MicroRNAs (miRNAs) are a class of small RNA molecules that are involved in cellular
posttranscriptional regulation. In this review, we describe some key features of miRNA …