An essential nuclear protein in trypanosomes is a component of mRNA transcription/export pathway

M Serpeloni, CB Moraes, JRC Muniz, MCM Motta… - PLoS …, 2011 - journals.plos.org
In eukaryotic cells, different RNA species are exported from the nucleus via specialized
pathways. The mRNA export machinery is highly integrated with mRNA processing, and …

The general mRNA exporters Mex67 and Mtr2 play distinct roles in nuclear export of tRNAs in Trypanosoma brucei

E Hegedűsová, S Kulkarni, B Burgman… - Nucleic acids …, 2019 - academic.oup.com
Transfer RNAs (tRNAs) are central players in protein synthesis, which in Eukarya need to be
delivered from the nucleus to the cytoplasm by specific transport receptors, most of which …

Identification of a novel nucleocytoplasmic shuttling RNA helicase of trypanosomes

AH Inoue, M Serpeloni, PM Hiraiwa… - PLoS …, 2014 - journals.plos.org
Gene expression in trypanosomes is controlled mostly by post-transcriptional pathways.
Little is known about the components of mRNA nucleocytoplasmic export routes in these …

Nuclear Compartmentalization Contributes to Stage-Specific Gene Expression Control in Trypanosoma cruzi

L Pastro, P Smircich, A Di Paolo, L Becco… - Frontiers in cell and …, 2017 - frontiersin.org
In the protozoan parasite Trypanosoma cruzi, as in other trypanosomatids, transcription of
protein coding genes occurs in a constitutive fashion, producing large polycistronic …

Proteomics uncovers novel components of an interactive protein network supporting RNA export in trypanosomes

AH Inoue, PF Domingues, M Serpeloni… - Molecular & Cellular …, 2022 - ASBMB
In trypanosomatids, transcription is polycistronic and all mRNAs are processed by trans-
splicing, with export mediated by noncanonical mechanisms. Although mRNA export is …

UAP56 is a conserved crucial component of a divergent mRNA export pathway in Toxoplasma gondii

M Serpeloni, E Jiménez‐Ruiz, NM Vidal… - Molecular …, 2016 - Wiley Online Library
Nucleo‐cytoplasmic RNA export is an essential post‐transcriptional step to control gene
expression in eukaryotic cells and is poorly understood in apicomplexan parasites. With the …

An RNA recognition motif mediates the nucleocytoplasmic transport of a trypanosome RNA-binding protein

A Cassola, AC Frasch - Journal of Biological Chemistry, 2009 - ASBMB
RNA-binding proteins (RBPs) and RNA metabolism are considered to be important for
modulating gene expression in trypanosomes, because these protozoan parasites mainly …

Insights into a CRM1-mediated RNA-nuclear export pathway in Trypanosoma cruzi

IC Cuevas, ACC Frasch, I D'Orso - Molecular and biochemical parasitology, 2005 - Elsevier
Nuclear export and import of proteins and RNAs is a regulated process that permits the
control of protein expression during cell development and differentiation. In all eukaryotic …

Nuclear tRNA export in trypanosomes: a journey full of twists and turns guided by tRNA modifications

Z Paris - Parasitology, 2021 - cambridge.org
Transfer RNAs play a key role in protein synthesis. Following transcription, tRNAs are
extensively processed prior to their departure from the nucleus to become fully functional …

Nuclear mRNA maturation and mRNA export control: from trypanosomes to opisthokonts

S Kramer - Parasitology, 2021 - cambridge.org
The passage of mRNAs through the nuclear pores into the cytoplasm is essential in all
eukaryotes. For regulation, mRNA export is tightly connected to the full machinery of nuclear …