Objective To compare long term recurrence of cancer and survival of patients having major
abdominal surgery for cancer. Design Long term follow-up of prospective randomised …

Background There is some evidence that epidural analgesia (EDA) reduces tumour
recurrence after breast and prostatic cancer surgery. We assessed whether EDA reduces …

In a primary analysis of a large recently completed randomized trial in 915 high-risk patients
undergoing major abdominal surgery, we found no difference in outcome between patients …

Background Thoracic epidural analgesia (TEA) has been suggested to improve survival
after curative surgery for colorectal cancer compared with systemic opioid analgesia. The …

Background Epidural block is widely used to manage major abdominal surgery and
postoperative analgesia, but its risks and benefits are uncertain. We compared adverse …

Introduction Animal studies suggest that regional anesthesia and optimal postoperative
analgesia independently reduce cancer metastasis. Retrospective clinical studies suggest …

Background Cancer recurrence after surgery may be affected by immunosuppressive factors
such as surgical stress, anesthetic drugs, and opioids. By limiting exposure to these …

Background The ideal perioperative analgesia should provide effective pain relief, avoid the
detrimental effects of the stress response, be simple to administer without the need for …

Background Because of the uncertainty and limitations in available randomized controlled
trials, we performed an analysis of the Medicare claims database to determine whether an …

Objective: To quantify benefit and harm of epidural analgesia, compared with systemic
opioid analgesia, in adults having surgery under general anesthesia. Background: It …