The chemokine receptor CXCR4 is a member of the seven transmembrane GPCR family,
which is implicated in multiple diseases, including HIV infection, cancers, and rheumatoid …

Several low molecular weight nonpeptide compounds having the dipicolylamine− zinc (II)
complex structure were identified as potent and selective antagonists of the chemokine …

The CXCR4 chemokine receptor is implicated in a number of diseases including HIV
infection and cancer development and metastasis. Previous studies have demonstrated that …

The important roles of the CXCL12/CXCR4 axis in numerous pathogenic pathways involving
HIV infection and cancer metastasis make the CXCR4 receptor an attractive target for the …

A zinc (II) containing configurationally restricted analogue of bismacrocyclic cyclam-type
CXCR4 chemokine receptor antagonists has been synthesized and shown to adopt only …

The chemokine receptor CXCR4 has been proposed as a drug target based on its important
functions in HIV infection, inflammation/autoimmune diseases and cancer metastasis …

Chemokine receptors are a target of growing interest for new therapeutic drugs, as their role
in multiple disease states has been demonstrated. The CXCR4/CXCL12 pairing has been …

The chemokine receptor CXCR4/stromal cell-derived factor-1 (SDF-1: CXCL12) signaling
axis represents a crucial drug target due to its relevance to several diseases such as HIV-1 …

Combination therapy with reverse transcriptase and protease inhibitors greatly reduces
morbidity and mortality in HIV-1-infected individuals. However, current anti-retroviral …

The chemokine receptor CXCR4 acts as a key cell surface receptor in HIV infections,
multiple forms of cancer, and various other pathologies, such as rheumatoid arthritis and …