Epigenetic marking of the BDNF gene by early-life adverse experiences
TL Roth, JD Sweatt - Hormones and behavior, 2011 - Elsevier
Studies over the past half-century have made it clear that environmental influences in
development, particularly stress and traumatic experiences, can remain pervasive across …
development, particularly stress and traumatic experiences, can remain pervasive across …
Lasting epigenetic influence of early-life adversity on the BDNF gene
BACKGROUND: Childhood maltreatment and early trauma leave lasting imprints on neural
mechanisms of cognition and emotion. With a rat model of infant maltreatment by a …
mechanisms of cognition and emotion. With a rat model of infant maltreatment by a …
Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development
There has been a dramatic rise in gene× environment studies of human behavior over the
past decade that have moved the field beyond simple nature versus nurture debates. These …
past decade that have moved the field beyond simple nature versus nurture debates. These …
The intergenerational effects of early adversity
J Galler, DG Rabinowitz - Progress in molecular biology and translational …, 2014 - Elsevier
Early insults during critical periods of brain development, both prenatal and postnatal, can
result in epigenetic changes that may impact health and behavioral outcomes over the life …
result in epigenetic changes that may impact health and behavioral outcomes over the life …
Prenatal stress differentially alters brain-derived neurotrophic factor expression and signaling across rat strains
EW Neeley, R Berger, JI Koenig, S Leonard - Neuroscience, 2011 - Elsevier
Background. Psychiatric illness and anxiety disorders have strong neurodevelopmental
components. Environmental insults such as prenatal exposure to stress and genetic …
components. Environmental insults such as prenatal exposure to stress and genetic …
Epigenetic modifications induced by early enrichment are associated with changes in timing of induction of BDNF expression
During early postnatal phase, the environment deeply affects developmental trajectories
through epigenetic mechanisms that control the levels of key molecules for brain function …
through epigenetic mechanisms that control the levels of key molecules for brain function …
Changes in neuroplasticity following early-life social adversities: the possible role of brain-derived neurotrophic factor
C Miskolczi, J Halász, É Mikics - Pediatric Research, 2019 - nature.com
Social adversities experienced in childhood can have a profound impact on the developing
brain, leading to the emergence of psychopathologies in adulthood. Despite the burden this …
brain, leading to the emergence of psychopathologies in adulthood. Despite the burden this …
Early adversity and developmental outcomes: Interaction between genetics, epigenetics, and social experiences across the life span
FA Champagne - Perspectives on psychological science, 2010 - journals.sagepub.com
Longitudinal studies in humans demonstrate the association between prenatal and
postnatal experiences of adversity and long-term changes in neurodevelopment. These …
postnatal experiences of adversity and long-term changes in neurodevelopment. These …
Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence
M Li, W Du, F Shao, W Wang - Behavioural brain research, 2016 - Elsevier
Early life adversity, such as social isolation, causes a variety of changes to the development
of cognitive abilities and the nervous system. Increasing evidence has shown that epigenetic …
of cognitive abilities and the nervous system. Increasing evidence has shown that epigenetic …
[HTML][HTML] Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the …
A Nair, KC Vadodaria, SB Banerjee… - …, 2007 - nature.com
Stress regulation of brain-derived neurotrophic factor (BDNF) is implicated in the
hippocampal damage observed in depression. BDNF has a complex gene structure with …
hippocampal damage observed in depression. BDNF has a complex gene structure with …
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