Studies over the past half-century have made it clear that environmental influences in
development, particularly stress and traumatic experiences, can remain pervasive across …

BACKGROUND: Childhood maltreatment and early trauma leave lasting imprints on neural
mechanisms of cognition and emotion. With a rat model of infant maltreatment by a …

There has been a dramatic rise in gene× environment studies of human behavior over the
past decade that have moved the field beyond simple nature versus nurture debates. These …

Early insults during critical periods of brain development, both prenatal and postnatal, can
result in epigenetic changes that may impact health and behavioral outcomes over the life …

Background. Psychiatric illness and anxiety disorders have strong neurodevelopmental
components. Environmental insults such as prenatal exposure to stress and genetic …

During early postnatal phase, the environment deeply affects developmental trajectories
through epigenetic mechanisms that control the levels of key molecules for brain function …

Social adversities experienced in childhood can have a profound impact on the developing
brain, leading to the emergence of psychopathologies in adulthood. Despite the burden this …

Longitudinal studies in humans demonstrate the association between prenatal and
postnatal experiences of adversity and long-term changes in neurodevelopment. These …

Early life adversity, such as social isolation, causes a variety of changes to the development
of cognitive abilities and the nervous system. Increasing evidence has shown that epigenetic …

Stress regulation of brain-derived neurotrophic factor (BDNF) is implicated in the
hippocampal damage observed in depression. BDNF has a complex gene structure with …