The discovery of the gene mutation responsible for Huntington's disease (HD), huntingtin, in
1993 allowed for a better understanding of the pathology of and enabled the development of …

Huntington's disease (HD) is caused by an abnormal expansion of CAG repeats in the gene
encoding huntingtin. The development of therapies for HD requires preclinical testing of …

Huntington's disease is a neurodegenerative disorder, caused by an elongation of CAG
repeats in the huntingtin gene. Mice with an insertion of an expanded polyglutamine repeat …

Transgenic models representing Huntington's disease (HD) have proved useful for
understanding the cascade of molecular events leading to the disease. We report an initial …

Huntington's disease (HD) is a progressive neurodegenerative disease characterized by
progressive atrophy of the striatum, cerebral cortex, and white matter tracks. Major …

Huntington's disease is an autosomal dominant inherited disorder, caused by an expanded
polyglutamine region of a protein called huntingtin with unknown function. Transgenic mice …

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an
expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock‐in …

Huntington's disease (HD) is caused by the expansion of the polyglutamine tract expressed
in the huntingtin protein. Data from patients show a strong negative correlation between …

Our previous work has established a huntingtin knock-in (KI) pig model that displays striatal
neuronal loss, allowing us to examine if somatic CAG expansion in striatum accounts for the …

Huntington's disease (HD) is an autosomal, dominantly inherited neurodegenerative
disorder that is characterized by abnormal involuntary movements (chorea), intellectual …