Mucosal surfaces are colonized by large communities of commensal bacteria and represent
the primary site of entry for pathogenic agents. To prevent microbial intrusion, mucosal B …

Humoral immune responses at mucosal surfaces have historically focused on IgA. Growing
evidence highlights the complexity of IgA-inducing pathways and the functional impact of IgA …

The majority of activated B cells differentiate into IgA plasma cells, with the gut being the
largest producer of immunoglobulin in the body. Secretory IgA antibodies have numerous …

IgA class switching is the process whereby B cells acquire the expression of IgA, the most
abundant antibody isotype in mucosal secretions. IgA class switching occurs via both T-cell …

Among antibodies, IgA is unique because it has evolved to be secreted onto mucosal
surfaces. The structure of IgA and the associated secretory component allow IgA to survive …

Various immune mechanisms are deployed in the mucosa to confront the immense diversity
of resident bacteria. A substantial fraction of the commensal microbiota is coated with …

The human intestine is densely colonized with commensal microbes that stimulate the
immune system. While secretory Immunoglobulin (Ig) A is known to play a crucial role in gut …

Most antibodies produced in the body are of the IgA class. The dominant cell population
producing them are plasma cells within the lamina propria of the gastrointestinal tract, but …

INTRODUCTION Immunoglobulin A (IgA) is the most abundant mammalian antibody
isotype, constituting more than 80% of all antibody-secreting plasma cells at steady state …

Immunoglobulin A is the main element of the humoral immune response that has been
selected through evolution, together with innate mucosal defences, to provide protection …