CCR3, a G protein‐coupled receptor, plays a central role in allergic inflammation and is an
important drug target for inflammatory diseases. To understand the structure–function …

Chemokine receptors are G protein-coupled receptors that contain seven transmembrane
domains. In particular, CCR2 and CCR5 and their ligands have been implicated in the …

CCR2 and CCR5 receptors play a key role in the development and progression of several
inflammatory, cardiovascular and autoimmune diseases. Therefore, dual targeting of both …

Importance of the field: CC-chemokine receptor 2 (CCR2) belongs to the GPCR superfamily
and is the primary receptor for monocyte chemoattractant protein-1 (MCP-1), also known as …

The viral resistance of marketed antiviral drugs including the emergence of new viral
resistance of the only marketed CCR5 entry inhibitor, maraviroc, makes it necessary to …

In the present study, we have used an approach combining protein structure modeling,
molecular dynamics (MD) simulation, automated docking, and 3D QSAR analyses to …

Anibamine, a novel pyridine quaternary alkaloid recently isolated from Aniba sp., has been
found to effectively bind to the chemokine receptor CCR5 with an IC50 at 1 μM in …

A hit-to-lead optimization process was carried out on the high throughput screening hit
compound 1 resulting in the identification of several potent and selective CCR1 receptor …

CC chemokine receptor 5 (CCR5), a member of G protein-coupled receptors (GPCRs), plays
a vital role in inflammatory responses to infection. Alterations in the expression of CCR5 …

A three-dimensional model of the chemokine receptor CCR5 has been built to fulfill
structural peculiarities of its α-helix bundle and to distinguish known CCR5 antagonists from …