The mechanisms for vascular calcification and its associated cardiovascular mortality in
patients with ESRD are not completely understood. Dialysis patients exhibit profound …

Background and objectives: Vitamin K-dependent matrix Gla protein (MGP) acts as a
calcification inhibitor in vitro and in vivo. The present study was performed to (1) determine …

Abstract Background Matrix Gla protein (MGP) is known to act as a potent local inhibitor of
vascular calcifications. However, in order to be active, MGP must be phosphorylated and …

Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification. The ability of MGP to
inhibit calcification requires the activity of a vitamin K–dependent enzyme, which mediates …

Background Arterial calcification is associated with cardiovascular mortality in dialysis
patients. Active matrix Gla protein (MGP) is a vitamin K-dependent inhibitor of arterial …

Background/Aims: Desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) is formed as
a result of vitamin K insufficiency. The aim of this study was to investigate the association …

Arterial calcification is highly prevalent in chronic kidney disease (CKD) patients and is
associated with cardiovascular (CV) morbidity and mortality. Patients at early CKD stages …

BACKGROUND: Vascular calcification is a predictor of cardiovascular morbidity and
mortality. Hemodialysis patients experience severe vascular calcifications. Matrix Gla protein …

The cardinal biological role of vitamin K is to act as cofactor for the carboxylation of a
number of vitamin K-dependent proteins, some of which are essential for coagulation, bone …

Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification (VC) and requires
carboxylation by vitamin K to exert calcification inhibition. Chronic kidney disease (CKD) …