Stress during early life can impact the developing brain and increase vulnerability to mood
disorders later in life. Here, we argue that epigenetic mechanisms can mediate the gene …

Early-life stress induces persistent memory traces on our genes and programs the life-long
risk for depression. Epigenetic marking of the arginine vasopressin (AVP) gene by early-life …

Adverse early life events can induce long-lasting changes in physiology and behavior. We
found that early-life stress (ELS) in mice caused enduring hypersecretion of corticosterone …

Early-life stress (ELS) increases the vulnerability thresholds for stress-related diseases such
as major depression and anxiety by inducing alterations in the structure and function of …

Early-life stress (ELS) in mice causes sustained hypomethylation at the downstream Avp
enhancer, subsequent overexpression of hypothalamic Avp and increased stress …

The hypothalamic‐pituitary‐adrenal axis provides physiological adaptations to various
environmental stimuli in mammals. These stimuli including maternal care, diet, immune …

The hypothalamic–pituitary–adrenal (HPA) axis is critically involved in the neuroendocrine
regulation of stress adaptation, and the restoration of homeostasis following stress …

Studies show that adverse conditions during early life can increase risks of developing
mood disorders later in life. It is currently hypothesized that levels of environmental adversity …

The functioning of the hypothalamic–pituitary–adrenal (HPA) axis and serotonergic (5-HT)
system are known to be intertwined with mood. Alterations in these systems are often …

Mutations in the X-linked gene MECP2, the founding member of a family of proteins
recognizing and binding to methylated DNA, are the genetic cause of a devastating …