Ovarian cancer causes more deaths than any other gynecologic malignancy in developed
countries. Sixteen million sequence variants, identified through whole-genome sequencing …

Germline loss-of-function mutations in BRCA1 interacting protein C-terminal helicase 1
(BRIP1) are associated with ovarian carcinoma and may also contribute to breast cancer …

Background: Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy,
responsible for 13 000 deaths per year in the United States. Risk prediction based on …

Background Germline mutations in the BRIP1 gene have been described as conferring a
moderate risk for ovarian cancer (OC), while the role of BRIP1 in breast cancer (BC) …

Background It is estimated that more than 20% of ovarian cancer cases are associated with
a genetic predisposition that is only partially explained by germline mutations in the BRCA1 …

Background BRCA1 interacting protein C-terminal helicase 1 (BRIP1) is one of the Fanconi
Anaemia Complementation (FANC) group family of DNA repair proteins. Biallelic mutations …

We identified constitutional truncating mutations of the BRCA1-interacting helicase BRIP1 in
9/1,212 individuals with breast cancer from BRCA1/BRCA2 mutation–negative families but …

Objective Genetic predisposition to ovarian cancer is well documented. With the advent of
next generation sequencing, hereditary panel testing provides an efficient method for …

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological
malignancy in the developed world, accounting for 4% of the deaths from cancer in women …

Inherited loss-of-function mutations in BRCA1 and BRCA2 and other tumor suppressor
genes predispose to ovarian carcinomas, but the overall burden of disease due to inherited …