Vulnerability to drug abuse is related to both reward seeking and impulsivity, two constructs
thought to have a biological basis in the prefrontal cortex (PFC). This review addresses …

The prelimbic region (PL) of the medial prefrontal cortex (mPFC) is implicated in the relapse
of drug-seeking behavior. Optimal mPFC functioning relies on synaptic connections …

Addiction is characterized by compulsive drug use despite negative consequences. Here we
review studies that indicate that compulsive drug use, and in particular punishment …

Risky decision making is a hallmark behavioral phenotype of drug abuse; thus, an
understanding of its biological bases may inform efforts to develop therapies for addictive …

Increasing evidence indicates that substance abusers are impaired in cognitive–executive
control tasks relying on different functional systems converging in the prefrontal cortex …

Addiction is characterized by compulsive drug use despite adverse consequences. The
precise psychobiological changes that underlie the progression from casual use to loss of …

Drug addiction can be defined by a compulsion to seek and take drug, loss of control in
limiting intake, and the emergence of a negative emotional state when access to the drug is …

Alcohol and substance abuse disorders involve continued use of substances despite
negative consequences, ie loss of behavioral control of drug use. The frontal-cortical areas …

Regular drug use can lead to addiction, but not everyone who takes drugs makes this
transition. How exactly drugs of abuse interact with individual vulnerability is not fully …

A principal feature of drug addiction is a reduced ability to regulate control over the desire to
procure drugs regardless of the risks involved. Traditional models implicated the neural …