Developmentally, the fetal GnRH pulse generator and its activation of the downstream
gonadotrope and gonadal axis in humans is fully operational in both sexes by the end of the …

Evolutionary survival of a species is largely a function of its reproductive fitness. In
mammals, a sparsely populated and widely dispersed network of hypothalamic neurons, the …

Recent advances in the use of gonadotropin-releasing hormone (GnRH) promoter-driven
transgenics in the mouse are beginning to open up the once elusive GnRH neuronal …

The neuroendocrine regulation of reproduction is an intricate process requiring the exquisite
coordination of an assortment of cellular networks, all converging on the GnRH neurons …

The pulsatile secretion of GnRH from normal and immortalized hypothalamic GnRH neurons
is highly calcium-dependent and is stimulated by cAMP. It is also influenced by agonist …

Cells containing gonadotropin-releasing hormone (GnRH) are essential not only for
reproduction but also for neuromodulatory functions in the adult animal. A variety of studies …

Gonadotropin-releasing hormone (GnRH) is a crucial neurohormone regulating puberty and
reproduction in non primate mammals, monkeys and humans. This neuropeptide is released …

Hypothalamic secretion of gonadotropin-releasing hormone (GnRH) has been established
as a principle pathway for initiating and integrating female reproductive function. GnRH …

Introduction T THESE are exciting times for clinicians and investigators interested in how the
brain controls reproduction in the human. Patients with GnRH deficiency present to the …

Demonstrating marked variability across the life cycle, yet exquisitely regulated, the
hypothalamic secretion of GnRH in the human triggers a cascade of events leading to …