The early life social environment and DNA methylation: DNA methylation mediating the long-term impact of social environments early in life

M Szyf - Epigenetics, 2011 - Taylor & Francis
Although epidemiological data provides evidence that there is an interaction between
genetics (nature) and the social and physical environments (nurture) in human …

DNA methylation: a mechanism for embedding early life experiences in the genome

M Szyf, J Bick - Child development, 2013 - Wiley Online Library
Although epidemiological data provide evidence that early life experience plays a critical
role in human development, the mechanism of how this works remains in question. Recent …

DNA methylation, behavior and early life adversity

M Szyf - Journal of Genetics and Genomics, 2013 - Elsevier
The impact of early physical and social environments on life-long phenotypes is well known.
Moreover, we have documented evidence for gene–environment interactions where …

DNA methylation at the crossroads of gene and environment interactions

PP Law, ML Holland - Essays in biochemistry, 2019 - portlandpress.com
DNA methylation is an epigenetic mark involved in regulating genome function and is critical
for normal development in mammals. It has been observed that the developmental …

[HTML][HTML] DNA methylation, early life environment, and health outcomes

C Mitchell, LM Schneper, DA Notterman - Pediatric research, 2016 - nature.com
Epigenetics, and especially DNA methylation, have recently become provocative biological
explanations for early-life environmental effects on later health. Despite the large increase in …

The social environment and the epigenome

M Szyf, P McGowan, MJ Meaney - … and molecular mutagenesis, 2008 - Wiley Online Library
The genome is programmed by the epigenome. Two of the fundamental components of the
epigenome are chromatin structure and covalent modification of the DNA molecule itself by …

[HTML][HTML] DNA methylation, the early-life social environment and behavioral disorders

M Szyf - Journal of Neurodevelopmental Disorders, 2011 - Springer
One of the outstanding questions in behavioral disorders is untangling the complex
relationship between nurture and nature. Although epidemiological data provide evidence …

Environmental signaling and evolutionary change: can exposure of pregnant mammals to environmental estrogens lead to epigenetically induced evolutionary …

C Guerrero‐Bosagna, P Sabat… - Evolution & …, 2005 - Wiley Online Library
DNA methylation is one of the epigenetic and hereditary mechanisms regulating genetic
expression in mammalian cells. In this review, we propose how certain natural agents …

The dynamic nature of DNA methylation: a role in response to social and seasonal variation

S Alvarado, RD Fernald, KB Storey… - … and comparative biology, 2014 - academic.oup.com
An organism's ability to adapt to its environment depends on its ability to regulate and
maintain tissue specific, temporal patterns of gene transcription in response to specific …

Environmental impact on DNA methylation in the germline: state of the art and gaps of knowledge

F Pacchierotti, M Spanò - BioMed research international, 2015 - Wiley Online Library
The epigenome consists of chemical changes in DNA and chromatin that without modifying
the DNA sequence modulate gene expression and cellular phenotype. The epigenome is …