Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
EK Speliotes, LM Yerges-Armstrong, J Wu… - PLoS …, 2011 - journals.plos.org
Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common
genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic …
genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic …
[PDF][PDF] Characterization of European ancestry nonalcoholic fatty liver disease‐associated variants in individuals of African and Hispanic descent
Nonalcoholic fatty liver disease (NAFLD) is an obesity‐related condition affecting over 50%
of individuals in some populations and is expected to become the number one cause of liver …
of individuals in some populations and is expected to become the number one cause of liver …
Genome-wide association study identifies variants associated with histologic features of nonalcoholic fatty liver disease
BACKGROUND & AIMS: Little data are available from genome-wide association studies
(GWASs) of liver histology in patients with nonalcoholic fatty liver disease (NAFLD). We …
(GWASs) of liver histology in patients with nonalcoholic fatty liver disease (NAFLD). We …
GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network
B Namjou, T Lingren, Y Huang, S Parameswaran… - BMC medicine, 2019 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver illness with
a genetically heterogeneous background that can be accompanied by considerable …
a genetically heterogeneous background that can be accompanied by considerable …
[HTML][HTML] Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort☆
Background & Aims Genetic factors associated with non-alcoholic fatty liver disease
(NAFLD) remain incompletely understood. To date, most genome-wide association studies …
(NAFLD) remain incompletely understood. To date, most genome-wide association studies …
Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a complex disease linked to several chronic
diseases. We aimed at identifying genetic variants associated with NAFLD and evaluating …
diseases. We aimed at identifying genetic variants associated with NAFLD and evaluating …
Toward genetic prediction of nonalcoholic fatty liver disease trajectories: PNPLA3 and beyond
M Krawczyk, R Liebe, F Lammert - Gastroenterology, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is on the verge of becoming the leading cause of
liver disease. NAFLD develops at the interface between environmental factors and inherited …
liver disease. NAFLD develops at the interface between environmental factors and inherited …
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem of unknown
etiology that varies in prevalence among ancestry groups. To identify genetic variants …
etiology that varies in prevalence among ancestry groups. To identify genetic variants …
Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is common and partially heritable and has no
effective treatments. We carried out a genome-wide association study (GWAS) meta …
effective treatments. We carried out a genome-wide association study (GWAS) meta …
Genetic and environmental susceptibility to non-alcoholic fatty liver disease
CP Day - Digestive diseases, 2010 - karger.com
While the majority of those with non-alcoholic fatty liver disease (NAFLD) will have simple
hepatic steatosis, a minority will develop progressive steatohepatitis. Family studies and …
hepatic steatosis, a minority will develop progressive steatohepatitis. Family studies and …