Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
We used cross-linking and immunoprecipitation coupled with high-throughput sequencing to
identify binding sites in 6,304 genes as the brain RNA targets for TDP-43, an RNA binding …
identify binding sites in 6,304 genes as the brain RNA targets for TDP-43, an RNA binding …
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies in
frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The …
frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The …
TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD
Cytoplasmic aggregation of TDP-43, accompanied by its nuclear clearance, is a key
common pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia …
common pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia …
Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection
SE Avendaño-Vázquez, A Dhir, S Bembich… - Genes & …, 2012 - genesdev.cshlp.org
TDP-43 is a critical RNA-binding factor associated with pre-mRNA splicing in mammals. Its
expression is tightly autoregulated, with loss of this regulation implicated in human …
expression is tightly autoregulated, with loss of this regulation implicated in human …
Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability
TDP-43 is a nuclear protein involved in exon skipping and alternative splicing. Recently,
TDP-43 has been identified as the pathological signature protein in frontotemporal lobar …
TDP-43 has been identified as the pathological signature protein in frontotemporal lobar …
[HTML][HTML] RNA binding antagonizes neurotoxic phase transitions of TDP-43
TDP-43 proteinopathy is a pathological hallmark of amyotrophic lateral sclerosis and
frontotemporal dementia where cytoplasmic TDP-43 inclusions are observed within …
frontotemporal dementia where cytoplasmic TDP-43 inclusions are observed within …
[HTML][HTML] High-resolution RNA maps suggest common principles of splicing and polyadenylation regulation by TDP-43
Many RNA-binding proteins (RBPs) regulate both alternative exons and poly (A) site
selection. To understand their regulatory principles, we developed expressRNA, a web …
selection. To understand their regulatory principles, we developed expressRNA, a web …
TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein …
sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein …
RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy
R Ihara, K Matsukawa, Y Nagata… - Human molecular …, 2013 - academic.oup.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by
progressive and selective loss of motor neurons. The discovery of mutations in the gene …
progressive and selective loss of motor neurons. The discovery of mutations in the gene …
TDP-43-Mediated Neuron Loss In Vivo Requires RNA-Binding Activity
Alteration and/or mutations of the ribonucleoprotein TDP-43 have been firmly linked to
human neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and …
human neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and …