Regulation of Plasmodium falciparum virulence genes and immune response to surface antigens in placental malaria
K Brolin - 2011 - openarchive.ki.se
Malaria infection caused by the parasite Plasmodium falciparum is a deadly torment,
especially for young children and pregnant women residing in sub-Saharan Africa. Much of …
especially for young children and pregnant women residing in sub-Saharan Africa. Much of …
Epigenetics and chromatin structure regulate var2csa expression and the placental binding phenotype in Plasmodium falciparum
Plasmodium falciparum is responsible for what appears to be a never-ending public health
issue in the developing world. With repeated infections, a gradual semi-immunity to severe …
issue in the developing world. With repeated infections, a gradual semi-immunity to severe …
Molecular Aspects of Plasmodium falciparum Infection during Pregnancy
NT Ndam, P Deloron - BioMed Research International, 2007 - Wiley Online Library
Cytoadherence of Plasmodium-falciparum‐parasitized red blood cells (PRBCs) to host
receptors is the key phenomenon in the pathological process of the malaria disease. Some …
receptors is the key phenomenon in the pathological process of the malaria disease. Some …
Understanding how Plasmodium falciparum binds to the placenta and produces pathology provides a rationale for pregnancy-associated malaria vaccine …
LC Morley, AW Taylor-Robinson - The Open Vaccine Journal, 2012 - benthamopen.com
By adulthood repeated exposure to Plasmodium falciparum, the causative agent of the most
severe form of malaria in humans, can induce semi-immunity to clinical infection. During …
severe form of malaria in humans, can induce semi-immunity to clinical infection. During …
The immunology and pathogenesis of malaria during pregnancy
Women in endemic areas become highly susceptible to malaria during first and second
pregnancies, despite immunity acquired after years of exposure. Recent insights have …
pregnancies, despite immunity acquired after years of exposure. Recent insights have …
MicroReview: The role of Plasmodium falciparum var genes in malaria in pregnancy
JA Rowe, SA Kyes - Molecular microbiology, 2004 - Wiley Online Library
Sequestration of Plasmodium falciparum‐infected erythrocytes in the placenta is responsible
for many of the harmful effects of malaria during pregnancy. Sequestration occurs as a result …
for many of the harmful effects of malaria during pregnancy. Sequestration occurs as a result …
Evaluation of the Antigenic Diversity of Placenta-Binding Plasmodium falciparum Variants and the Antibody Repertoire among Pregnant Women
M Hommel, SR Elliott, V Soma, G Kelly… - Infection and …, 2010 - Am Soc Microbiol
Pregnant women are infected by specific variants of Plasmodium falciparum that adhere and
accumulate in the placenta. Using serological and molecular approaches, we assessed the …
accumulate in the placenta. Using serological and molecular approaches, we assessed the …
[PDF][PDF] Plasticity and diversity of the Plasmodium falciparum placental malaria antigen VAR2CSA
E Talundzic - 2013 - getd.libs.uga.edu
Malaria in pregnancy is a disease syndrome with devastating social and medical
complications requiring multidimensional solutions. Despite intensified international efforts …
complications requiring multidimensional solutions. Despite intensified international efforts …
Towards the rational design of a candidate vaccine against pregnancy associated malaria: conserved sequences of the DBL6ε domain of VAR2CSA
C Badaut, G Bertin, T Rustico, N Fievet… - PLoS …, 2010 - journals.plos.org
Background Placental malaria is a disease linked to the sequestration of Plasmodium
falciparum infected red blood cells (IRBC) in the placenta, leading to reduced materno-fetal …
falciparum infected red blood cells (IRBC) in the placenta, leading to reduced materno-fetal …
Polymorphic Molecular Signatures in Variable Regions of the Plasmodium falciparum var2csa DBL3x Domain Are Associated with Virulence in Placental Malaria
The Plasmodium falciparum protein VAR2CSA allows infected erythrocytes to accumulate
within the placenta, inducing pathology and poor birth outcomes. Multiple exposures to …
within the placenta, inducing pathology and poor birth outcomes. Multiple exposures to …