Regulation of Plasmodium falciparum virulence genes and immune response to surface antigens in placental malaria

K Brolin - 2011 - openarchive.ki.se
Malaria infection caused by the parasite Plasmodium falciparum is a deadly torment,
especially for young children and pregnant women residing in sub-Saharan Africa. Much of …

Epigenetics and chromatin structure regulate var2csa expression and the placental binding phenotype in Plasmodium falciparum

T Lenz, M Sirel, H Hoppe, S Shafeeq, K Le Roch… - bioRxiv, 2023 - biorxiv.org
Plasmodium falciparum is responsible for what appears to be a never-ending public health
issue in the developing world. With repeated infections, a gradual semi-immunity to severe …

Molecular Aspects of Plasmodium falciparum Infection during Pregnancy

NT Ndam, P Deloron - BioMed Research International, 2007 - Wiley Online Library
Cytoadherence of Plasmodium-falciparum‐parasitized red blood cells (PRBCs) to host
receptors is the key phenomenon in the pathological process of the malaria disease. Some …

Understanding how Plasmodium falciparum binds to the placenta and produces pathology provides a rationale for pregnancy-associated malaria vaccine …

LC Morley, AW Taylor-Robinson - The Open Vaccine Journal, 2012 - benthamopen.com
By adulthood repeated exposure to Plasmodium falciparum, the causative agent of the most
severe form of malaria in humans, can induce semi-immunity to clinical infection. During …

The immunology and pathogenesis of malaria during pregnancy

JG Beeson, PE Duffy - Immunology and Immunopathogenesis of Malaria, 2005 - Springer
Women in endemic areas become highly susceptible to malaria during first and second
pregnancies, despite immunity acquired after years of exposure. Recent insights have …

MicroReview: The role of Plasmodium falciparum var genes in malaria in pregnancy

JA Rowe, SA Kyes - Molecular microbiology, 2004 - Wiley Online Library
Sequestration of Plasmodium falciparum‐infected erythrocytes in the placenta is responsible
for many of the harmful effects of malaria during pregnancy. Sequestration occurs as a result …

Evaluation of the Antigenic Diversity of Placenta-Binding Plasmodium falciparum Variants and the Antibody Repertoire among Pregnant Women

M Hommel, SR Elliott, V Soma, G Kelly… - Infection and …, 2010 - Am Soc Microbiol
Pregnant women are infected by specific variants of Plasmodium falciparum that adhere and
accumulate in the placenta. Using serological and molecular approaches, we assessed the …

[PDF][PDF] Plasticity and diversity of the Plasmodium falciparum placental malaria antigen VAR2CSA

E Talundzic - 2013 - getd.libs.uga.edu
Malaria in pregnancy is a disease syndrome with devastating social and medical
complications requiring multidimensional solutions. Despite intensified international efforts …

Towards the rational design of a candidate vaccine against pregnancy associated malaria: conserved sequences of the DBL6ε domain of VAR2CSA

C Badaut, G Bertin, T Rustico, N Fievet… - PLoS …, 2010 - journals.plos.org
Background Placental malaria is a disease linked to the sequestration of Plasmodium
falciparum infected red blood cells (IRBC) in the placenta, leading to reduced materno-fetal …

Polymorphic Molecular Signatures in Variable Regions of the Plasmodium falciparum var2csa DBL3x Domain Are Associated with Virulence in Placental Malaria

E Talundzic, S Scott, SO Owino, DS Campo, NW Lucchi… - Pathogens, 2022 - mdpi.com
The Plasmodium falciparum protein VAR2CSA allows infected erythrocytes to accumulate
within the placenta, inducing pathology and poor birth outcomes. Multiple exposures to …