ATM is the most significant molecule involved in monitoring the genomic integrity of the cell.
Any damage done to DNA relentlessly challenges the cellular machinery involved in …

ATM, mutation of which causes Ataxia telangiectasia, has emerged as a cardinal
multifunctional protein kinase during past two decades as evidenced by various studies from …

The Ataxia Telangiectasia Mutated gene encodes the ATM protein, a key element in the
DNA damage response (DDR) signalling pathway responsible for maintaining genomic …

The ATM protein kinase is the product of the gene responsible for the pleiotropic recessive
disorder ataxia-telangiectasia. ATM-deficient cells show enhanced sensitivity and greatly …

ATM is among of the most critical initiators and coordinators of the DNA-damage response.
ATM canonical and non-canonical signaling pathways involve hundreds of downstream …

ABSTRACT ATM and ATR signaling pathways are well conserved throughout evolution and
are central to the maintenance of genome integrity. Although the role of both ATM and ATR …

The DNA damage response (DDR) rapidly recognizes DNA lesions and initiates the
appropriate cellular programs to maintain genome integrity. This includes the coordination of …

Ataxia-telangiectasia mutated (ATM) kinase is a one of the main guardian of genome
stability and plays a central role in the DNA damage response (DDR). The deregulation of …

One of the cornerstones of the web of signaling pathways governing cellular life and
differentiation is the DNA damage response. It spans a complex network of pathways …

The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an
apical activator of the DNA damage response in the face of DNA double-strand breaks …