Comprehensive clinical studies show that adverse conditions in early life can severely
impact the developing brain and increase vulnerability to mood disorders later in life. During …

Stressor exposure during early life has the potential to increase an individual's susceptibility
to a number of neuropsychiatric conditions such as mood and anxiety disorders and …

Epigenetic processes have profound influence on gene translation and play a key role in
embryonic development and tissue type specification. Recent advances in our …

Risk for neuropsychiatric disorders is complex and includes an individual's internal genetic
endowment and their environmental experiences and exposures. Embryonic development …

Exposure to early life stress (ELS), such as childhood abuse and neglect is a well
established major risk factor for developing psychiatric and behavioral disorders later in life …

Adaptation to environmental changes is based on the perpetual generation of new
phenotypes. Modern biology has focused on the role of epigenetic mechanisms in …

Early life adversity is associated with long-term effects on physical and mental health later in
life, but the mechanisms are yet unclear. Epigenetic mechanisms program cell-type-specific …

Childhood adversity can have life-long consequences for the response to stressful events
later in life. Abuse or severe neglect are well-known risk factors for post-traumatic stress …

The impact that stressful encounters have upon long-lasting behavioural phenotypes is
varied. Whereas a significant proportion of the population will develop “stress-related” …

A deeper understanding of the pathomechanisms leading to stress-related psychiatric
disorders is important for the development of more efficient preventive and therapeutic …