Epigenetics of early child development
C Murgatroyd, D Spengler - Frontiers in psychiatry, 2011 - frontiersin.org
Comprehensive clinical studies show that adverse conditions in early life can severely
impact the developing brain and increase vulnerability to mood disorders later in life. During …
impact the developing brain and increase vulnerability to mood disorders later in life. During …
Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders
Stressor exposure during early life has the potential to increase an individual's susceptibility
to a number of neuropsychiatric conditions such as mood and anxiety disorders and …
to a number of neuropsychiatric conditions such as mood and anxiety disorders and …
Epigenetic dynamics in psychiatric disorders: environmental programming of neurodevelopmental processes
Epigenetic processes have profound influence on gene translation and play a key role in
embryonic development and tissue type specification. Recent advances in our …
embryonic development and tissue type specification. Recent advances in our …
Prenatal stress and genetic risk: How prenatal stress interacts with genetics to alter risk for psychiatric illness
PW Abbott, SB Gumusoglu, J Bittle… - …, 2018 - Elsevier
Risk for neuropsychiatric disorders is complex and includes an individual's internal genetic
endowment and their environmental experiences and exposures. Embryonic development …
endowment and their environmental experiences and exposures. Embryonic development …
The effects of early life stress on the epigenome: from the womb to adulthood and even before
N Provençal, EB Binder - Experimental neurology, 2015 - Elsevier
Exposure to early life stress (ELS), such as childhood abuse and neglect is a well
established major risk factor for developing psychiatric and behavioral disorders later in life …
established major risk factor for developing psychiatric and behavioral disorders later in life …
Integrating early life experience, gene expression, brain development, and emergent phenotypes: unraveling the thread of nature via nurture
ICG Weaver - Advances in genetics, 2014 - Elsevier
Adaptation to environmental changes is based on the perpetual generation of new
phenotypes. Modern biology has focused on the role of epigenetic mechanisms in …
phenotypes. Modern biology has focused on the role of epigenetic mechanisms in …
The epigenetics of perinatal stress
M Szyf - Dialogues in clinical neuroscience, 2019 - Taylor & Francis
Early life adversity is associated with long-term effects on physical and mental health later in
life, but the mechanisms are yet unclear. Epigenetic mechanisms program cell-type-specific …
life, but the mechanisms are yet unclear. Epigenetic mechanisms program cell-type-specific …
Epigenomic mechanisms of early adversity and HPA dysfunction: considerations for PTSD research
PO McGowan - Frontiers in psychiatry, 2013 - frontiersin.org
Childhood adversity can have life-long consequences for the response to stressful events
later in life. Abuse or severe neglect are well-known risk factors for post-traumatic stress …
later in life. Abuse or severe neglect are well-known risk factors for post-traumatic stress …
Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders
The impact that stressful encounters have upon long-lasting behavioural phenotypes is
varied. Whereas a significant proportion of the population will develop “stress-related” …
varied. Whereas a significant proportion of the population will develop “stress-related” …
Epigenetics of stress-related psychiatric disorders and gene× environment interactions
A deeper understanding of the pathomechanisms leading to stress-related psychiatric
disorders is important for the development of more efficient preventive and therapeutic …
disorders is important for the development of more efficient preventive and therapeutic …