Baculovirus as a gene delivery vector: recent understandings of molecular alterations in transduced cells and latest applications

CY Chen, CY Lin, GY Chen, YC Hu - Biotechnology advances, 2011 - Elsevier
Baculovirus infects insects in nature and is non-pathogenic to humans, but can transduce a
broad range of mammalian and avian cells. Thanks to the biosafety, large cloning capacity …

Baculoviruses in gene therapy and personalized medicine

S Schaly, M Ghebretatios, S Prakash - Biologics: Targets and …, 2021 - Taylor & Francis
This review will outline the role of baculoviruses in gene therapy and future potential in
personalized medicine. Baculoviruses are a safe, non-toxic, non-integrative vector with a …

[HTML][HTML] Baculovirus: an insect-derived vector for diverse gene transfer applications

KJ Airenne, YC Hu, TA Kost, RH Smith, RM Kotin… - Molecular Therapy, 2013 - cell.com
Insect-derived baculoviruses have emerged as versatile and safe workhorses of
biotechnology. Baculovirus expression vectors (BEVs) have been applied widely for crop …

Baculovirus vectors for gene therapy

YC Hu - Advances in virus research, 2006 - Elsevier
Since the discovery that baculoviruses can efficiently transduce mammalian cells,
baculoviruses have been extensively studied as potential vectors for both in vitro and in vivo …

Baculovirus for gene delivery to mammalian cells: Past, present and future

M Mansouri, P Berger - Plasmid, 2018 - Elsevier
Baculovirus is an insect virus which has been used for more than thirty years for production
of recombinant proteins in insect cells. However, baculovirus can also be harnessed for …

[HTML][HTML] Baculovirus as a tool for gene delivery and gene therapy

C Ono, T Okamoto, T Abe, Y Matsuura - Viruses, 2018 - mdpi.com
Based on its ability to express high levels of protein, baculovirus has been widely used for
recombinant protein production in insect cells for more than thirty years with continued …

Baculoviral vectors for gene delivery: a review

YC Hu - Current gene therapy, 2008 - ingentaconnect.com
Baculovirus has emerged as a novel vector for in vivo and in vitro gene delivery. In addition,
the applications of baculovirus-mediated gene transfer have been explosively expanded to …

Thirty years of baculovirus–insect cell protein expression: from dark horse to mainstream technology

MM Van Oers, GP Pijlman… - Journal of General …, 2015 - microbiologyresearch.org
In December 1983, a seminal paper appeared on the overexpression of human IFN-β in
insect cells with a genetically engineered baculovirus. The finding that baculoviruses …

Towards the use of baculovirus as a gene therapy vector.

L Pieroni, N La Monica - Current Opinion in Molecular Therapeutics, 2001 - europepmc.org
The use of baculovirus vectors for gene expression in mammalian cells is in continuous
expansion. These vectors do not replicate in mammalian cells, do not cause a cytopathic …

Baculovirus as an expression and/or delivery vehicle for vaccine antigens

YC Hu, K Yao, TY Wu - Expert review of vaccines, 2008 - Taylor & Francis
The baculovirus/insect cell-expression system has proven to be a valuable tool for rapid
expression of abundant recombinant proteins for research purposes and has been …