Malignant melanoma is one the most aggressive types of cancer and its incidence has
gradually increased in the last years, accounting for about 75% of skin cancer deaths. This …

Shikonin, a natural product isolated from the roots of Lithospermum erythrorhizon, exhibits
pharmacological effects against inflammation, ulcers, infections, and tumors. In the present …

Natural phytochemicals and their derivatives are good drug candidates for anticancer
therapeutic approaches against multiple targets. We report here the initial findings from our …

Background The plant-derived terpenoid, α-pinene is a bicyclic monoterpene potentially
useful for the treatment of various diseases which also includes cancer and its types. The …

Apoptosis is regarded as a therapeutic target because it is typically disturbed in human
cancer. Silymarin from milk thistle (Silybum marianum) has been reported to exhibit …

Hesperetin, a flavanone glycoside predominantly found in citrus fruits, exhibits a wide array
of biological properties. In the present study hesperetin exhibited a significant cytotoxic effect …

Background Shikonin is the main naphthoquinone compound of the root of Lithospermum
erythrorhizon. Our previous study demonstrated that shikonin possesses anticancer activity …

Cancer is known as a leading cause of death worldwide. In the last two decades, the
incidence of cancer has been dramatically increased mostly due to lifestyle changes. The …

Shikonin is a main constituent of the roots of Lithospermum erythrorhizon that has
antimutagenic activity. However, its other biological activities are not well-known. Shikonin …

Background Cancer has been one of the leading causes of mortality in this era. Ruta
angustifolia L. Pers has been traditionally used as an abortifacient, antihelmintic …