Defective recruitment, survival and proliferation of bone marrow-derived progenitor cells at sites of delayed diabetic wound healing in mice

M Albiero, L Menegazzo, E Boscaro, C Agostini… - Diabetologia, 2011 - Springer
Aims/hypothesis Bone marrow (BM)-derived endothelial progenitor cells (EPC) promote
tissue healing and angiogenesis, whereas altered EPC biology may favour diabetic …

The mobilization and effect of endogenous bone marrow progenitor cells in diabetic wound healing

P Fiorina, G Pietramaggiori, SS Scherer… - Cell …, 2010 - journals.sagepub.com
Diabetic patients suffer from impaired wound healing, characterized by only modest
angiogenesis and cell proliferation. Stem cells may stimulate healing, but little is known …

Differentiation of bone marrow-derived endothelial progenitor cells is shifted into a proinflammatory phenotype by hyperglycemia

CJM Loomans, R van Haperen, JM Duijs… - Molecular …, 2009 - Springer
Bone marrow (BM)-derived endothelial progenitor cells (EPC) contribute to vascular
maintenance by participating in angiogenesis, re-endothelialization, and remodeling …

Leprdb Diabetic Mouse Bone Marrow Cells Inhibit Skin Wound Vascularization but Promote Wound Healing

V Stepanovic, O Awad, C Jiao, M Dunnwald… - Circulation …, 2003 - Am Heart Assoc
Bone marrow stem cells participate in tissue repair processes and may have roles in skin
wound repair. Diabetes is characterized by delayed and poor wound healing, and type 1 …

Topical application of ex vivo expanded endothelial progenitor cells promotes vascularisation and wound healing in diabetic mice

J Asai, H Takenaka, M Ii, M Asahi… - International wound …, 2013 - Wiley Online Library
Impaired wound healing leading to skin ulceration is a serious complication of diabetes and
may be caused by defective angiogenesis. Endothelial progenitor cells (EPCs) can augment …

Impaired endothelial progenitor cell mobilization and dysfunctional bone marrow stroma in diabetes mellitus

PE Westerweel, M Teraa, S Rafii, JE Jaspers, IA White… - PloS one, 2013 - journals.plos.org
Background Circulating Endothelial Progenitor Cell (EPC) levels are reduced in diabetes
mellitus. This may be a consequence of impaired mobilization of EPC from the bone marrow …

Decreased mobilization of endothelial progenitor cells contributes to impaired neovascularization in diabetes

L Kang, Q Chen, L Wang, L Gao… - Clinical and …, 2009 - Wiley Online Library
Summary 1 Circulating bone marrow (BM)‐derived endothelial progenitor cells (EPCs) play
an important role in neovascularization. In the present study, we investigated the …

Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes

CJM Loomans, EJP de Koning, FJT Staal… - Diabetes, 2004 - Am Diabetes Assoc
Type 1 diabetes is associated with reduced vascular repair, as indicated by impaired wound
healing and reduced collateral formation in ischemia. Recently, endothelial progenitor cells …

[HTML][HTML] Bone marrow–derived endothelial progenitor cells do not contribute significantly to new vessels during incisional wound healing

JE Bluff, MWJ Ferguson, S O'Kane, G Ireland - Experimental hematology, 2007 - Elsevier
OBJECTIVE: To assess the contribution of bone marrow (BM)-derived endothelial progenitor
cells (EPCs) to the neovascularisation of cutaneous incisional wounds. METHODS: Lethally …

A reappraisal of the role of circulating (progenitor) cells in the pathobiology of diabetic complications

GP Fadini - Diabetologia, 2014 - Springer
Traditionally, the development of diabetic complications has been attributed to the
biochemical pathways driving hyperglycaemic cell damage, while reparatory mechanisms …