LIV-1 promotes prostate cancer epithelial-to-mesenchymal transition and metastasis through HB-EGF shedding and EGFR-mediated ERK signaling

HW Lue, X Yang, R Wang, W Qian, RZH Xu, R Lyles… - PloS one, 2011 - journals.plos.org
LIV-1, a zinc transporter, is an effector molecule downstream from soluble growth factors.
This protein has been shown to promote epithelial-to-mesenchymal transition (EMT) in …

LIV-1 enhances the aggressive phenotype through the induction of epithelial to mesenchymal transition in human pancreatic carcinoma cells

J Unno, K Satoh, M Hirota… - International …, 2009 - spandidos-publications.com
LIV-1 is a downstream target of STAT3 and is essential for the nuclear localization of Snail, a
master regulator of epithelial to mesenchymal transition (EMT). Little is known about the …

Negative correlation of LIV-1 and E-cadherin expression in hepatocellular carcinoma cells

R Shen, F Xie, H Shen, Q Liu, T Zheng, X Kou, D Wang… - PloS one, 2013 - journals.plos.org
LIV-1, a zinc transporter, is a mediator downstream of STAT3 both in zebrafish and
mammalian cells, and is involved in epithelial-mesenchymal transition (EMT). Despite LIV-1 …

Livin regulates prostate cancer cell invasion by impacting the NF‐κB signaling pathway and the expression of FN and CXCR4

F Chen, D Yang, S Wang, X Che, J Wang, X Li… - IUBMB …, 2012 - Wiley Online Library
Prostate cancer (PCa) has the second highest mortality rate of all tumor‐related diseases for
males in Western countries, and the incidence of PCa in China is increasing. Previous …

Livin‐α promotes cell proliferation by regulating G1‐S cell cycle transition in prostate cancer

L Ye, X Song, S Li, D Yang, J Zhang, X Che… - The …, 2011 - Wiley Online Library
BACKGROUND Prostate cancer is the third most common cancer and the second leading
cause of cancer death for males in US. Livin has recently been described as a cancer …

LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway

L Zhao, W Chen, KM Taylor, B Cai, X Li - Biochemical and biophysical …, 2007 - Elsevier
It was reported that expression of the estrogen-regulated zinc transporter LIV-1 was
particularly high in human cervical cancer cell line HeLa. This result prompted us to study …

Livin promotes progression of breast cancer through induction of epithelial–mesenchymal transition and activation of AKT signaling

F Li, X Yin, X Luo, HY Li, X Su, XY Wang, L Chen… - Cellular signalling, 2013 - Elsevier
The inhibitor of apoptosis proteins (IAP) are closely correlated with proliferation, apoptosis,
motility, and metastasis. Livin is the most recently identified IAP, and its role in breast …

Expression levels of the putative zinc transporter LIV‐1 are associated with a better outcome of breast cancer patients

G Kasper, AA Weiser, A Rump… - … journal of cancer, 2005 - Wiley Online Library
We investigated the expression pattern of the breast cancer associated gene LIV‐1 on
mRNA and protein level in 111 human breast cancer patients by in situ hybridization as well …

Concordant correlation of LIV-1 and E-cadherin expression in human breast cancer cell MCF-7

H Shen, H Qin, J Guo - Molecular biology reports, 2009 - Springer
The recent report highlighted a significant association between signal transducer and
activator of transcription 3 (STAT3) and Snail and LIV-1 (SLC39A6 or ZIP6), the breast …

The emerging role of the LIV-1 subfamily of zinc transporters in breast cancer

KM Taylor, HE Morgan, K Smart, NM Zahari… - Molecular …, 2007 - Springer
Abstract Zinc transporter LIV-1 (SLC39A6) is estrogen regulated and present in increased
amounts in estrogen receptor-positive breast cancer as well as in tumors that spread to the …