Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix,
where they interact with a plethora of ligands. Over the last decade, new insights have …

Proteoglycan (PG) coreceptors carry heparan sulfate (HS) chains that mediate interactions
with growth factors, morphogens, and receptors. Thus, PGs modulate fundamental …

Receptor-ligand interactions play an important role in many biological processes by
triggering specific cellular responses. These interactions are frequently regulated by …

Cell surface heparan sulfate proteoglycans (HSPGs), 1 substantially more abundant than
most receptors, modulate encounters of extracellular protein ligands with their receptors by …

Heparan sulfate proteoglycans are complex molecules composed of a core protein with
covalently attached glycosaminoglycan chains. While the protein part determines …

Large numbers of proteins in animal tissues occur immobilized in the extracellular space, at
cell surfaces or in the extracellular matrix. Some are anchored through interactions with …

Heparan sulfate (HS) proteoglycans (PGs) are ubiquitously expressed on cell surfaces and
in the extracellular matrix of most animal tissues, having essential functions in development …

J. Clin. Invest. 108: 165–167 (2001). DOI: 10.1172/JCI200113560. away. Thus, heparan
sulfate could easily cross a fullthickness basement membrane and touch an adjacent cell …

Heparan sulfate (HS) is a component of cell surface and matrix-associated proteoglycans
(HSPGs) that, collectively, play crucial roles in many physiologic processes including cell …

Proteoglycans are abundant components of the cell surface and extracellular matrix that
mediate critical interactions between cells and their environment. They play a variety of …