Poly (ADP)-ribose polymerase (PARP) inhibitors modify the enzymatic activity of PARP1/2.
When certain PARP inhibitors are used either alone or in combination with DNA damage …

Understanding the impact of the p53 tumor suppressor pathway on the regulation of genome
integrity, cancer development, and cancer treatment has intrigued scientists and clinicians …

The deletion of the gene coding for poly (ADP-ribose) polymerase-1 (PARP1) or its
pharmacological inhibition protects mice against cerebral ischemia and Parkinson's …

Poly (ADP-ribose) polymerase-1 (PARP-1) plays a primary role in the process of poly (ADP-
ribosyl) ation. This posttranslational modification of nuclear proteins is activated in response …

PARP-3, a DNA-dependent PARP with emerging roles in double-strand break repair and
mitotic progression Page 1 www.landesbioscience.com Cell Cycle 1023 Cell Cycle 10:7 …

Abstract Poly (ADP-ribose) polymerase 1 (PARP1) and PARP2 are recruited and activated
by DNA damage, resulting in ADP-ribosylation at numerous sites, both within PARP1 itself …

PARP1 and PARP2 detect DNA breaks, which activates their catalytic production of poly
(ADP-ribose) that recruits repair factors and contributes to PARP1/2 release from DNA …

PARP-1 is a nuclear protein that has important roles in maintenance of genomic integrity.
During genotoxic stress, PARP-1 recruits to sites of DNA damage where PARP-1 domain …

The tumour supressor protein p53 plays a key role in the cell's decision to arrest the cell
cycle or undergo apoptosis following a genotoxic insult. p53 is stabilized and activated after …

PARP inhibitor tilts cell death from necrosis to apoptosis in cancer cells Page 1 942 Cancer
Biology & Therapy 2008; Vol. 7 Issue 6 [Cancer Biology & Therapy 7:6, 942-944; June 2008]; …