A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells
AW Kao, RJ Eisenhut, LH Martens… - Proceedings of the …, 2011 - National Acad Sciences
Frontotemporal lobar degeneration is a progressive neurodegenerative syndrome that is the
second most common cause of early-onset dementia. Mutations in the progranulin gene are …
second most common cause of early-onset dementia. Mutations in the progranulin gene are …
Progranulin expression in the developing and adult murine brain
TL Petkau, SJ Neal, PC Orban… - Journal of …, 2010 - Wiley Online Library
Frontotemporal lobar degeneration (FTLD) is a neurodegenerative condition characterized
by focal degeneration of the frontal and temporal lobes of the brain. Autosomal dominantly …
by focal degeneration of the frontal and temporal lobes of the brain. Autosomal dominantly …
Structure, function, and mechanism of progranulin; the brain and beyond
H Toh, BP Chitramuthu, HPJ Bennett… - Journal of Molecular …, 2011 - Springer
Mutation of human GRN, the gene encoding the secreted glycoprotein progranulin, results in
a form of frontotemporal lobar degeneration that is characterized by the presence of …
a form of frontotemporal lobar degeneration that is characterized by the presence of …
[HTML][HTML] Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
P Van Damme, A Van Hoecke… - The Journal of cell …, 2008 - ncbi.nlm.nih.gov
Recently, mutations in the progranulin (PGRN) gene were found to cause familial and
apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in …
apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in …
Progranulin: normal function and role in neurodegeneration
JL Eriksen, IRA Mackenzie - Journal of neurochemistry, 2008 - Wiley Online Library
Progranulin (PGRN) is a multifunctional protein that has attracted significant attention in the
neuroscience community following the recent discovery of PGRN mutations in some cases …
neuroscience community following the recent discovery of PGRN mutations in some cases …
[HTML][HTML] Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging
Z Ahmed, H Sheng, Y Xu, WL Lin, AE Innes… - The American journal of …, 2010 - Elsevier
Progranulin (PGRN) is involved in wound repair, inflammation, and tumor formation, but its
function in the central nervous system is unknown. Roles in development, sexual …
function in the central nervous system is unknown. Roles in development, sexual …
Core neuropathological abnormalities in progranulin-deficient mice are penetrant on multiple genetic backgrounds
TL Petkau, A Hill, BR Leavitt - Neuroscience, 2016 - Elsevier
Loss-of-function mutations in the progranulin gene (GRN) are a common cause of familial
frontotemporal lobar degeneration (FTLD). A high degree of heterogeneity in the age-of …
frontotemporal lobar degeneration (FTLD). A high degree of heterogeneity in the age-of …
Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β
Progranulin (PGRN) has recently emerged as a key player in a subset of frontotemporal
dementias (FTD). Numerous mutations in the progranulin gene have been identified in …
dementias (FTD). Numerous mutations in the progranulin gene have been identified in …
[HTML][HTML] Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia
F Yin, M Dumont, R Banerjee, Y Ma, H Li… - The FASEB …, 2010 - ncbi.nlm.nih.gov
Progranulin haploinsufficiency causes frontotemporal dementia with tau-negative, ubiquitin-
positive neuronal inclusion pathology. In this study, we showed that progranulin-deficient …
positive neuronal inclusion pathology. In this study, we showed that progranulin-deficient …
Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration
GRN mutations cause frontotemporal lobar degeneration with TDP-43-positive inclusions.
The mechanism of pathogenesis is haploinsufficiency. Recently, homozygous GRN …
The mechanism of pathogenesis is haploinsufficiency. Recently, homozygous GRN …