The sirtuin gene family comprises an evolutionarily ancient set of NAD+ dependent protein
deacetylase and mono-ADP ribosyltransferase enzymes. Found in all domains of life …

Aging is characterized by a cumulative loss of genome integrity, which involves chromatin
reorganization, transcriptional dysregulation and the accumulation of DNA damage. Sirtuins …

Sirtuin 6 (SIRT6) is a mammalian homolog of the yeast Sir2 deacetylase. Mice deficient for
SIRT6 exhibit genome instability. Here, we show that in mammalian cells subjected to …

Sirtuins, a family of protein deacetylases, promote cellular homeostasis by mediating
communication between cells and environment. The enzymatic activity of the mammalian …

Mammalian sirtuin 6 (Sirt6) is a conserved NAD+-dependent deacylase and mono-ADP
ribosylase that is known to be involved in DNA damage repair, metabolic homeostasis …

Cellular DNA is constantly challenged by damage-inducing factors derived from exogenous
or endogenous sources. Thus, to protect against DNA damage, cells have evolved complex …

Cells evolve to actively coordinate nutrient availability with cellular activity in order to
maintain metabolic homeostasis. In addition, active pathways to repair DNA damage are …

Abstract Sirtuins (SIRTs 1− 7), or class III histone deacetylases (HDACs), are protein
deacetylases/ADP ribosyltransferases that target a wide range of cellular proteins in the …

Abstract Human sirtuin 3 (SIRT3) is a conserved NAD+ dependent deacetylase, which
functions in important cellular processes including transcription, metabolism, oxidative stress …

The sirtuins are highly conserved NAD‐dependent deacetylases that were shown to
regulate lifespan in lower organisms and affect diseases of aging in mammals, such as …