The chemokine, CXCL10, and its cognate receptor, CXCR3, are important mediators of the
pathobiology of lung fibrosis. Macrophages are a known source of CXCL10, but their …

The lung is continuously exposed to bacteria and their products, and has developed a
complex defense mechanism, including neutrophil recruitment. In mice, keratinocyte cell …

CXC chemokine receptor 3 (CXCR3) is the receptor for the IFN-γ–inducible CXC
chemokines MIG/CXCL9, IP-10/CXCL10, and I-TAC/CXCL11. CXCR3 is expressed on …

Acute pulmonary inflammation is still a frightening complication in intensive care units and
has a high mortality. Specific treatment is not available, and many details of the …

Restoration of the epithelial barrier following acute lung injury is critical for recovery of lung
homeostasis. After injury, alveolar type II epithelial (ATII) cells spread and migrate to cover …

Abstract The C‑X‑C Motif Chemokine Receptor 4/C‑X‑C Motif Chemokine Ligand 12
(CXCR4/CXCL12) axis has been implicated in the pathogenesis of pulmonary fibrosis …

Background During acute lung injury, lung fibroblasts produce chemokines that assist the
activation and migration of resident macrophages. The interactions between pulmonary …

The mucosal immune network is a crucial barrier preventing pathogens from entering the
body. The network of immune cells that mediates the defensive mechanisms in the mucosa …

Chemokines are a superfamily of chemotactic cytokines that direct the movement of cells
throughout the body under homeostatic and inflammatory conditions. The mucosal …

In models of acute lung injury, CXC chemokine receptor 2 (CXCR2) mediates migration of
polymorphonuclear leukocytes (PMNs) into the lung. Since CXCR2 ligands, including …