Background The potential impact of intraoperative analgesics on oncological outcome after
radical prostatectomy is debated. Some investigators have suggested that use of opioids …

Background Systemic opioids are immunosuppressive, which could promote tumour
recurrence. We, therefore, test the hypothesis that supplementing general anaesthesia with …

Background Regional anesthesia and analgesia attenuate or prevent perioperative factors
that favor minimal residual disease after removal of the primary carcinoma. Therefore, the …

Aims: To determine whether the use neuraxial anesthesia/analgesia is associated with
longer biochemical recurrence-free survival (BRFS) and overall survival (OS) after radical …

Background Prostate cancer is one of the most prevalent neoplasms in male patients, and
surgery is the main treatment. Opioids can have immune modulating effects, but their …

BACKGROUND: The use of regional anesthesia for cancer surgery has been associated
with improved oncologic outcomes. One of the proposed mechanisms is a reduction in the …

Background A beneficial effect of regional anesthesia on cancer related outcome in various
solid tumors has been proposed. The data on prostate cancer is conflicting and reports on …

Background Recently published studies suggest that the anesthetic technique used during
oncologic surgery affects cancer recurrence. To evaluate the effect of anesthetic technique …

Introduction Recent data suggest that using additional neuroaxial anaesthesia during
oncological surgery is associated with favourable recurrence-free survival, when compared …

Conclusion No difference was observed between the epidural and control groups in disease-
free survival at a median follow-up time of 4.5 years. There is a need for large randomized …