Tyrosine kinase inhibitors are currently one of the most important classes of cancer drugs,
essentially because many kinases and regulators are molecules related to frequently …

Target therapies for the treatment of human cancers have revolutionized the concept of
oncological medicine. This type of therapeutic approach is directed to the inhibition of …

The old-fashioned anticancer approaches, aiming at arresting cancer cell proliferation
interfering with non-specific targets (eg DNA), have been replaced, in the last decades, by …

Prostate cancer is a significant public health problem around the world. Once a patient has
disease that is no longer addressable by local means, the cancer is considered incurable …

Signal transduction in cancer cells is a sophisticated process that involves receptor tyrosine
kinases (RTKs) that eventually trigger multiple cytoplasmic kinases, which are often …

Introduction: Prostate cancer (PCa) is the most frequently diagnosed, non-cutaneous
malignancy in Western countries. Until recently, few therapeutic options were available for …

En pratique clinique, le dysfonctionnement de certaines tyrosine-kinases sert de marqueur
pronostique ou/et prédictif chez les patients atteints de cancer, renseignant sur l'aspect …

Over the last decades, billions have been spent and huge efforts have been taken in basic
and clinical cancer research [CA Cancer J Clin 63: 11-30]. About a decade ago, the arms …

Highlights•Solid cancers are molecular complex and heterogeneous diseases.•Genomic
complexity and heterogeneity are the main culprits for the limited response to selective …

Despite recent advances in our understanding of the biological basis of prostate cancer, the
management of the disease, especially in the castration-resistant phase, remains a …