Integrin α9β1 mediates accelerated cell adhesion and migration through interactions with a
number of diverse extracellular ligands. We have shown previously that it directly binds the …

Vascular endothelial growth factor A (VEGF-A) is a potent inducer of angiogenesis. We now
show that VEGF-A-induced adhesion and migration of human endothelial cells are …

Angiogenesis is a complex process, involving functional cooperativity between cytokines
and endothelial cell (EC) surface integrins. In this study, we investigated the mechanisms …

The integrin α9β1 binds a number of extracellular matrix components to mediate cell
adhesion, migration and tissue invasion. Although expressed in a variety of normal human …

Mice homozygous for a null mutation of the integrin α9 subunit die 6–12 days after birth from
bilateral chylothoraces suggesting an underlying defect in lymphatic development. However …

The precise role of vascular endothelial growth factor (VEGF) in regulating integrins in brain
microvascular endothelial cells is unknown. Here, we analyzed VEGF effects on integrin …

Integrins, transmembrane glycoprotein receptors, play vital roles in pathological
angiogenesis, but their precise regulatory functions are not completely understood and …

Interaction between integrin α v β 3 and extracellular matrix is crucial for endothelial cells
sprouting from capillaries and for angiogenesis. Furthermore, integrin‐mediated outside‐in …

Vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase receptor for
several growth factors of the VEGF family. Endothelial cells express a membrane-spanning …

Interactions between integrins and tyrosine kinase receptors can modulate a variety of cell
functions. We observed a cooperative interaction between the β 1 integrin and vascular …