In CXC chemokines, two conserved C residues are separated by one unconserved amino
acid. These mediators chemoattract neutrophils, lymphocytes and monocytes into the …

Chemokines induce migration of inflammatory cells. In the synovial tissue of rheumatoid
arthritis (RA), abundant chemokines are expressed, which contribute migration of …

Chemokines are involved in leukocyte recruitment to inflammatory sites, such as the
synovial tissue in rheumatoid arthritis (RA). There is a structural and a functional …

Targeting chemokines and/or chemokine receptors appears to be an intriguing new
approach to treating chronic inflammatory disorders like rheumatoid arthritis, inflammatory …

Background: Chemokines and their receptors are considered important contributors in cell
migration and inflammation in chronic inflammatory disorders. Chemokines affecting …

Blockade of chemokines or chemokine receptors is emerging as a new potential treatment
for various immune-mediated conditions. This review focuses on the therapeutic potential in …

Chemokine receptors play a crucial role in the recruitment of leucocyte subsets into inflamed
tissue. Using FACS analysis we have studied the surface expression of different CC-and …

Chemokines are chemoattractant cytokines that direct the migration of leukocytes, and are
induced by inflammatory cytokines, growth factors and pathogenic stimuli (1). Chemokines …

Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction (1).
In RA, migration of leukocytes into the synovial tissue (ST) occurs. These leukocytes and …

Synovial inflammation in rheumatoid arthritis (RA) and other arthritides is, in part, dependent
on migration of inflammatory cells as well as retention of these cells at the site of …