The distinct cell types of the body are established from the fertilized egg in development and
assembled into functional tissues. Functional characteristics and gene expression patterns …

Repetitive elements comprise over two-thirds of the human genome. For a long time, these
elements have received little attention since they were considered non-functional. On the …

Gametes are among the most highly specialized cells produced during development.
Although gametogenesis culminates in transcriptional quiescence in plants and animals …

One fundamental aspect of biological sciences is to understand how different cell fates are
established during development and how cellular identity is maintained in adulthood. The …

Polycomb repressive complexes (PRCs) establish and maintain gene repression through
chromatin modifications, but their specific roles in cell fate determination events are poorly …

Heart disease is a leading cause of death and disability in developed countries. Heart
disease includes a broad range of diseases that affect the development and/or function of …

Priming of lineage‐specific genes in pluripotent embryonic stem cells facilitates rapid and
coordinated activation of transcriptional programmes during differentiation. There is growing …

Pluripotency is maintained by a complex system that includes the genetic and epigenetic
levels. Recent studies have shown that the genetic level (transcription factors, signal …

The remarkable promise of pluripotent and multipotent stem cells (SCs) imparts tremendous
optimism for advancement of regenerative medicine, developmental biology, and drug …

Previous epigenetics research in myelodysplastic syndromes (MDS) mainly focused on the
DNA methylation of tumor suppressor genes. Recent studies reported that around 6% of …