Pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, has a
major role in the induction of genes involved in drug transport and metabolism. Recent …

The RAS/MAP kinase pathway has attracted attention because activating mutations of the
BRAF serine/threonine kinase was described in over 50% of melanomas. Very recently …

The inhibitory kappa B kinases (IKKs) are well recognized as key regulators of the nuclear
factor kappa B (NF‐κB) cascade and as such represent a point of convergence for many …

Abstract Objective Platinum nanoparticles (nano-Pt) have been reported to possess anti-
oxidant and anti-tumor activities. However, the biological activity and mechanism of action of …

Cytokines have been implicated in a variety of physiological processes involving lymphoid
tissue development, lymphocyte activation, and control of regenerative processes such as …

The transcription factors of the Rel/NF‐κB family function as key regulators of innate and
adoptive immunity. Tightly and temporally controlled activation of NF‐κB‐signalling …

Influenza A virus (IAV) infection of epithelial cells activates NF-κB transcription factors via the
canonical NF-κB signaling pathway, which modulates both the antiviral immune response …

Histone acetylation via CBP/p300 coordinates the expression of proinflammatory cytokines
in the activation phase of inflammation, particularly through mitogen-activated protein …

The fusion of mononucleated muscle progenitor cells (myoblasts) into multinucleated
muscle fibers is a critical aspect of muscle development and regeneration. We identified the …

Inflammation conveys the development of glomerular injury and is a major cause of
progressive kidney disease. NF-κB signaling is among the most important regulators of …