NF-κB-inducing kinase (NIK) is a central component in the non-canonical NF-κB signaling
pathway. Excessive NIK activity is implicated in various disorders, such as autoimmune …

The failure of conventional vaccines or antimicrobials to combat newly emerging pathogens
such as new influenza viruses or antibiotic-resistant bacteria provides significant challenges …

The accumulation of damaged or postsynthetically modified proteins and dysregulation of
inflammatory responses and angiogenesis in the retina/RPE are thought be etiologically …

Both embryonic and adult neurogenesis involves the self-renewal/proliferation, survival,
migration and lineage differentiation of neural stem/progenitor cells. Such dynamic process …

The nuclear factor-kappa B (NFκB) signal transduction pathway plays an important role in
immunity, inflammation, cell growth, and survival. Since dysregulation of this pathway results …

The transcription factor nuclear factor-κB (NF-κB) is a main regulator of the expression of
several genes involved in the activation of inflammation, cell proliferation, cell immunity and …

Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has
been linked to cancer progression and metastasis. However, the mechanistic connection …

The transcription factor NF-κB has been causally linked to inflammatory lung diseases.
Recent studies have unraveled the complexity of NF-κB activation by identifying two parallel …

The HTLV-1 oncoprotein Tax is a potent activator of classical and alternative NF-κB
pathways and is thought to promote cell proliferation and transformation via NF-κB …

It is becoming clear that inflammation plays a significant role in a number of neurological
and psychiatric conditions. Post mortem brain samples in Alzheimer's disease, Parkinson's …