One of the major challenges in achieving effective anti-cancer immunotherapy is to
counteract immunological tolerance. Most tumor-associated antigens (TAAs) are sensed as …

Multiple transcription factors regulate B-cell commitment, which is coordinated with myeloid-
erythroid lineage differentiation. NF-κB has long been speculated to regulate early B-cell …

Central to NF-κB signaling pathways is IKKγ/NEMO, a regulatory subunit of the cytoplasmic
IκB kinase (IKK) complex, which undergoes various posttranslational modifications …

Triptolide (TPL) inhibits the proliferation of a variety of cancer cells and has been proposed
as an effective anticancer agent. In this study, we demonstrate that TPL downregulates …

On the basis of differential analysis of affinity purifications by mass spectrometry, we
identified the nuclear factor κB (NF-κB) protein p100 (NF-κB2) as an interactor of the F-box …

The recently emerged porcine reproductive and respiratory syndrome virus (PRRSV) leads
to one of the most economically significant infectious diseases of swine worldwide. The virus …

IκB kinase alpha (Ikk-α) gene mutations and IKK-α downregulation have been detected in
various human squamous cell carcinomas (SCCs), which are malignancies derived from …

Ectodermal dysplasia with immune deficiency (EDI) is an immunological and developmental
disorder caused by alterations in the gene encoding NF-κB essential modulator (NEMO; …

Glial cell line-derived neurotrophic factor (GDNF) is a potent protective factor for
dopaminergic (DA) neurons, but the signaling mechanisms underlying the effect of GDNF on …