Here we report the design, synthesis, and 5-HT7 receptor affinity of a set of 1-(3-biphenyl)-
and 1-(2-biphenyl) piperazines. The effect on 5-HT7 affinity of various substituents on the …

Thymoquinone (TQ) is the main bioactive component isolated from Nigella sativa essential
oil and seeds and has been used for the treatment of inflammations, liver disorders, arthritis …

Abstract Multi Drug Resistance (MDR) is one of the major causes of chemotherapy failure in
human malignancies. Curcumin, the active constituent of Curcuma longa is a proven …

The experimental induced circular dichroism (ICD) and absorption spectra of the achiral
flavonoid kaempferol upon binding to human serum albumin (HSA) were correlated to …

Human aldo-keto reductases 1C1–1C4 (AKR1C1–AKR1C4) function in vivo as 3-keto-, 17-
keto-, and 20-ketosteroid reductases and regulate the activity of androgens, estrogens, and …

Peptide–protein interactions are prevalent in the living cell and form a key component of the
overall protein–protein interaction network. These interactions are drawing increasing …

New drug discovery is considered broadly in terms of two kinds of investigational activities
such as exploration and exploitation. Docking of small molecules in the receptor binding site …

DNA damage occurs almost all the times in cells, but is repaired also continuously.
Occurrence of all these mutations and their accumulation in one cell which finally becomes …

There is a large emphasis within the pharmaceutical industry to provide tools that will allow
early research and development groups to better predict dose ranges for and metabolic …

The lysin motif (LysM) is a peptidoglycan binding protein domain found in a wide range of
prokaryotes and eukaryotes. Various techniques have been used to study the LysM–ligand …