Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo–keto reductase superfamily
Y Jin, L Duan, M Chen, TM Penning… - The Journal of steroid …, 2012 - Elsevier
Human ketosteroid reductases of the aldo–keto reductase (AKR) superfamily, ie AKR1C1–4,
are implicated in the biotransformation of synthetic steroid hormones. Norethynodrel (NOR …
are implicated in the biotransformation of synthetic steroid hormones. Norethynodrel (NOR …
Structural perspective on the direct inhibition mechanism of EGCG on mammalian histidine decarboxylase and DOPA decarboxylase
MV Ruiz-Pérez, A Pino-Angeles… - Journal of chemical …, 2012 - ACS Publications
Histidine decarboxylase (HDC) and l-aromatic amino acid decarboxylase (DDC) are
homologous enzymes that are responsible for the synthesis of important neuroactive amines …
homologous enzymes that are responsible for the synthesis of important neuroactive amines …
Discovering potent inhibitors against c-Met kinase: molecular design, organic synthesis and bioassay
The receptortyrosine kinase c-Met is an attractive target for therapeutic treatment of cancers
nowadays. The discovery of small molecule inhibitors is of special interest in the blockade of …
nowadays. The discovery of small molecule inhibitors is of special interest in the blockade of …
Discovery of potential cyclooxygenase inhibitors using in silico docking studies
A Madeswaran, M Umamaheswari… - Bangladesh Journal of …, 2012 - banglajol.info
This study deals with the evaluation of the cyclooxygenase inhibitory activity of flavonoids
(tangeritin, morin, rhamnetin, theaflavin, pachypodol, eriodictyol, homoeriodictyol …
(tangeritin, morin, rhamnetin, theaflavin, pachypodol, eriodictyol, homoeriodictyol …
Fluorescence detection of ligand binding to labeled cytochrome P450 BM3
The cytochrome P450 superfamily of monoxygenases are highly relevant for
pharmaceutical, environmental and biocatalytical applications. The binding of a substrate to …
pharmaceutical, environmental and biocatalytical applications. The binding of a substrate to …
On setting up and assessing docking simulations for virtual screening
Small molecule docking and virtual screening of candidate compounds have become an
integral part of drug discovery pipelines, complementing and streamlining experimental …
integral part of drug discovery pipelines, complementing and streamlining experimental …
[HTML][HTML] BioFET-SIM web interface: Implementation and two applications
We present a web interface which allows us to conveniently set up calculations based on the
BioFET-SIM model. With the interface, the signal of a BioFET sensor can be calculated …
BioFET-SIM model. With the interface, the signal of a BioFET sensor can be calculated …
Pathway-pathway network-based study of the therapeutic mechanisms by which salvianolic acid B regulates cardiovascular diseases
L Ye, Y He, H Ye, XP Liu, LL Yang, ZW Cao… - Chinese Science …, 2012 - Springer
Investigation of the potential therapeutic mechanisms of drug candidates is an essential step
in the process of new drug discovery. With the rapid development of systems biology, recent …
in the process of new drug discovery. With the rapid development of systems biology, recent …
[HTML][HTML] In silico design, construction and cloning of Trastuzumab humanized monoclonal antibody: a possible biosimilar for Herceptin
S Akbarzadeh-Sharbaf, B Yakhchali… - Advanced Biomedical …, 2012 - journals.lww.com
Background: There is a novel hypothesis in that antibodies may have specificity for two
distinct antigens that have been named “dual specificity”. This hypothesis was evaluated for …
distinct antigens that have been named “dual specificity”. This hypothesis was evaluated for …