Plasmodium falciparum's ability to invade erythrocytes is essential for its survival within the
human host. Immune mechanisms that impair this ability are therefore expected to contribute …

The main impetus for trying to understand immunity to malaria is the need to develop
effective malaria vaccines. Despite years of knowing that humans can be immune to malaria …

A broadly effective malaria vaccine is a missing component of the practical tools needed to
control and eventually eliminate malaria. For more than 50 years malaria researchers have …

Natural immunity against malaria is acquired after repeated infections for an extended
period of time resulting in a state of immunological non-responsiveness against the malaria …

Erythrocyte invasion is a key step in the Plasmodium life cycle. This process is tightly
regulated, involving the sequential release of specialised apical secretory organelles–the …

Erythrocytes play host to a range of intracellular organisms, including some of those from the
phylum Apicomplexa. The Apicomplexa are a large and diverse group of unicellular …

Abstract Complement receptor-type 1 (CR1, CD35) is the immune-adherence receptor, a
complement regulator, and an erythroid receptor for Plasmodium falciparum during …

This chapter contains sections titled: Introduction Discovery of High Affinity Parasite Ligands
and Receptors for Erythrocyte Invasion Identification of Multiple Erythrocyte Receptors for …

The following sections are included: Introduction Malaria and Plasmodial Parasites Parasite
Invasion, Erythrocyte Remodelling and Egress Parasite invasion Protein trafficking to the …