Because the initial reports demonstrating that circulating growth hormone and insulin-like
growth factor-1 decrease with age in laboratory animals and humans, there have been …

The beneficial effects of insulin and insulin-like growth factor I on cognition have been
documented in humans and animal models. Conversely, obesity, hyperinsulinemia, and …

Calorie restriction (CR), which deactivates the nutrient-sensing mTOR pathway, slows down
aging and prevents age-related diseases such as type II diabetes. Compared with CR …

Significant advances in understanding aging have been achieved through studying model
organisms with extended healthy lifespans. Employing 1H NMR spectroscopy, we …

Reducing the activity of the insulin/IGF‐1 signaling pathway (IIS) modifies development,
elevates stress resistance, protects from toxic protein aggregation (proteotoxicity), and …

Rapidly increasing numbers of older people present many countries with growing social and
economic challenges. Yet despite the far-reaching implications of ageing, its biological basis …

Dietary restriction (DR) is suggested to induce mitochondrial biogenesis, although recently
this has been challenged. Here we determined the impact of 1, 9 and 18 months of 30% DR …

Background Chronic dietary restriction (DR) has been shown to have beneficial effects on
glucose homeostasis and insulin sensitivity. These factors show rapid and robust …

Males, who are bigger and stronger than females, die younger in most species from flies to
mammals including humans. Cellular mass growth is driven in part by mTOR (Target of …

Numerous lines of evidence indicate that insulin-like growth factor signaling plays an
important role in the regulation of life span and tumor development. In the present paper, the …