Human embryonic stem cells (hESCs) are pluripotent cell types derived from the inner cell
mass of human blastocysts. Recent data indicate that the majority of established female XX …

Although the establishment of putative porcine embryonic stem cells (ESCs) has been
reported, such cell lines quickly lose their self-renewal ability, as they easily differentiate or …

Ion channels participate in cell homeostasis and are involved in the regulation of
proliferation and differentiation in several cell types; however, their presence and function in …

Rett syndrome (RTT) is a neurodevelopmental disorder that affects girls due primarily to
heterozygous mutations in the X-linked gene encoding methyl-CpG binding protein 2 …

Testing for embryotoxicity in vitro is an attractive alternative to animal experimentation. The
embryonic stem cell test (EST) is such a method, and it has been formally validated by the …

The ability to generate human pluripotent stem cells (hPSCs) holds great promise for the
understanding and the treatment of human neurological diseases in modern medicine. The …

Human somatic cells can be reprogrammed into induced pluripotent stem cells (hiPSCs)
with wide lineage differentiation potential in culture. However, reprogramming and long-term …

The induction of pluripotency can be achieved by forced expression of defined factors in
somatic cells. The established cells, termed induced pluripotent stem (iPS) cells, have …

The pluripotent state between human and mouse embryonic stem cells is different.
Pluripotent state of human embryonic stem cells (ESCs) is believed to be primed and is …

The factors limiting the rather inefficient derivation of human embryonic stem cells (HESCs)
are not fully understood. The aim of this study was to analyze the sex ratio in our 42 …