Resistance to obesity is becoming an exception rather than the norm, and understanding
mechanisms that lead some to remain lean in spite of an obesigenic environment is critical if …

Obesity has increased in prevalence worldwide, attributed in part to the influences of an
obesity-promoting environment and genetic factors. While obesity and overweight …

High levels of spontaneous physical activity in lean people and the nonexercise activity
thermogenesis (NEAT) derived from that activity appear to protect lean people from obesity …

There is significant variability in diet-induced obesity (DIO) among humans and rodents,
which has been associated with differences in intrinsic spontaneous physical activity (SPA) …

The orexins are neuropeptides with critical functions in the central nervous system. These
neuropeptides have important roles in energy balance and obesity, and therefore on the …

Obesity resistance due to elevated orexin signaling is accompanied by high levels of
spontaneous physical activity (SPA). The behavioral and neural mechanisms underlying this …

The orexin-A/hypocretin-1 and orexin-B/hypocretin-2 are neuropeptides synthesized by a
cluster of neurons in the lateral hypothalamus and perifornical area. Orexin neurons receive …

Obesity is a public health disease and its incidence is steadily increasing both in adults and
in children especially in the Western World. It is important to understand the underlying …

The orexin peptides and their two receptors are involved in multiple physiological
processes, including energy homeostasis, arousal, stress and reward. Higher signaling of …

Orexins/hypocretins and their receptors (OXRs) are ubiquitously distributed throughout the
nervous system and peripheral tissues. Recently, various reports have indicated that orexins …