Tracking the progression of the human inner cell mass during embryonic stem cell derivation

T O'leary, B Heindryckx, S Lierman… - Nature …, 2012 - nature.com
The different pluripotent states of mouse embryonic stem cells (ESCs) in vitro have been
shown to correspond to stages of mouse embryonic development,,,,,. For human cells, little …

Human embryonic stem cells: prospects for development

MF Pera, AO Trounson - 2004 - journals.biologists.com
It is widely anticipated that human embryonic stem (ES) cells will serve as an experimental
model for studying early development in our species, and, conversely, that studies of …

Embryonic stem cell identity grounded in the embryo

B Plusa, AK Hadjantonakis - Nature cell biology, 2014 - nature.com
Pluripotent embryonic stem cells (ESCs) can be derived from blastocyst-stage mouse
embryos. However, the exact in vivo counterpart of ESCs has remained elusive. A …

Pluripotent states of human embryonic stem cells

Y Chen, D Lai - … Reprogramming (Formerly" Cloning and Stem Cells …, 2015 - liebertpub.com
Since human embryonic stem cells (hESCs) were first isolated and successfully cultured in
vitro, the pluripotent potential of hESCs has been underestimated. The pluripotency of …

Uncovering the true identity of naive pluripotent stem cells

M Welling, N Geijsen - Trends in cell biology, 2013 - cell.com
Embryonic stem cells (ESCs) are pluripotent stem cells derived from the inner cell mass
(ICM) of blastocyst embryos. Although first characterized over 30 years ago, the ontology of …

Molecular and biological properties of pluripotent embryonic stem cells

S Ohtsuka, S Dalton - Gene therapy, 2008 - nature.com
The inner cell mass of pre-implantation blastocyst stage embryos is a source of cells that can
be cultured indefinitely in vitro as a self-renewing, pluripotent population. In this review, we …

The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification

T Boroviak, R Loos, P Bertone, A Smith, J Nichols - Nature cell biology, 2014 - nature.com
The precise relationship of embryonic stem cells (ESCs) to cells in the mouse embryo
remains controversial. We present transcriptional and functional data to identify the …

Metastable pluripotent states in NOD-mouse-derived ESCs

J Hanna, S Markoulaki, M Mitalipova, AW Cheng… - Cell stem cell, 2009 - cell.com
Embryonic stem cells (ESCs) are isolated from the inner cell mass (ICM) of blastocysts,
whereas epiblast stem cells (EpiSCs) are derived from the postimplantation epiblast and …

Transition of inner cell mass to embryonic stem cells: mechanisms, facts, and hypotheses

SN Hassani, S Moradi, S Taleahmad, T Braun… - Cellular and molecular …, 2019 - Springer
Embryonic stem cells (ESCs) are immortal stem cells that own multi-lineage differentiation
potential. ESCs are commonly derived from the inner cell mass (ICM) of pre-implantation …

Discovering pluripotency: 30 years of mouse embryonic stem cells

M Evans - Nature reviews Molecular cell biology, 2011 - nature.com
Embryonic stem (ES) cells are pluripotent cells isolated from an early embryo and grown as
a cell line in tissue culture. Their discovery came from the conjunction of studies in human …