Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine
J Weerachayaphorn, A Mennone… - American Journal …, 2012 - journals.physiology.org
The transcription factor nuclear factor-E2-related factor 2 (Nrf2) is a key regulator for
induction of hepatic detoxification and antioxidant mechanisms, as well as for certain …
induction of hepatic detoxification and antioxidant mechanisms, as well as for certain …
Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems
K Okada, J Shoda, K Taguchi, JM Maher… - Biochemical and …, 2009 - Elsevier
The transcription factor Nrf2 is a key regulator for hepatic induction of detoxifying enzymes,
antioxidative stress genes and Mrp efflux transporters. We aimed to investigate whether Nrf2 …
antioxidative stress genes and Mrp efflux transporters. We aimed to investigate whether Nrf2 …
Role of Nrf2 in the alteration of cholesterol and bile acid metabolism-related gene expression by dietary cholesterol in high fat-fed mice
T Kamisako, Y Tanaka, Y Kishino, T Ikeda… - Journal of clinical …, 2014 - jstage.jst.go.jp
抄録 Nuclear factor-E2-related factor 2 (Nrf2) is a regulator of lipid metabolism as well as
various cytoprotective enzymes and may be involved in the pathogenesis of non-alcoholic …
various cytoprotective enzymes and may be involved in the pathogenesis of non-alcoholic …
Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice
K Okada, J Shoda, K Taguchi… - American Journal …, 2008 - journals.physiology.org
The protective action of ursodeoxycholic acid (UDCA) in cholestatic liver diseases may be
mediated by choleresis, detoxification, and cytoprotection against oxidative stress. Nrf2, one …
mediated by choleresis, detoxification, and cytoprotection against oxidative stress. Nrf2, one …
[PDF][PDF] Nuclear factor erythroid 2–related factor 2 is a positive regulator of human bile salt export pump expression
J Weerachayaphorn, SY Cai, CJ Soroka… - Hepatology, 2009 - Wiley Online Library
The bile salt export pump (BSEP) is the major determinant of bile salt–dependent bile
secretion, and its deficiency leads to cholestatic liver injury. BSEP/Bsep gene expression is …
secretion, and its deficiency leads to cholestatic liver injury. BSEP/Bsep gene expression is …
Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450
Sister of P-glycoprotein (SPGP) is the major hepatic bile salt export pump (BSEP).
BSEP/SPGP expression varies dramatically among human livers. The potency and …
BSEP/SPGP expression varies dramatically among human livers. The potency and …
[PDF][PDF] Na+/H+ exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury
M Li, A Mennone, CJ Soroka, LR Hagey… - …, 2015 - Wiley Online Library
The intercellular adhesion molecule 1 (ICAM‐1) is induced in mouse liver after bile duct
ligation (BDL) and plays a key role in neutrophil‐mediated liver injury in BDL mice. ICAM‐1 …
ligation (BDL) and plays a key role in neutrophil‐mediated liver injury in BDL mice. ICAM‐1 …
Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression
S Xu, J Weerachayaphorn, SY Cai… - American Journal …, 2010 - journals.physiology.org
Multidrug resistance protein 4 (MRP4; ABCC4) is an ATP binding cassette transporter that
facilitates the excretion of bile salt conjugates and other conjugated steroids in hepatocytes …
facilitates the excretion of bile salt conjugates and other conjugated steroids in hepatocytes …
Participation of nuclear factor (erythroid 2‐related), factor 2 in ameliorating lithocholic acid‐induced cholestatic liver injury in mice
BACKGROUND AND PURPOSE Lithocholic acid (LCA), the most toxic bile acid, induces
cholestatic liver injury in rodents. We previously showed that LCA activates the oxidative …
cholestatic liver injury in rodents. We previously showed that LCA activates the oxidative …
Nuclear factor, erythroid 2-like 2 regulates expression of type 3 inositol 1, 4, 5-trisphosphate receptor and calcium signaling in cholangiocytes
J Weerachayaphorn, MJ Amaya, C Spirli, P Chansela… - Gastroenterology, 2015 - Elsevier
Background & Aims Most cholestatic disorders are caused by defects in cholangiocytes. The
type 3 isoform of the inositol 1, 4, 5-trisphosphate receptor (ITPR3) is the most abundant …
type 3 isoform of the inositol 1, 4, 5-trisphosphate receptor (ITPR3) is the most abundant …