[HTML][HTML] Cross-presentation and genome-wide screening reveal candidate T cells antigens for a herpes simplex virus type 1 vaccine
L Jing, J Haas, TM Chong, JJ Bruckner… - The Journal of …, 2012 - Am Soc Clin Investig
Herpes simplex virus type 1 (HSV-1) not only causes painful recurrent oral-labial infections,
it can also cause permanent brain damage and blindness. There is currently no HSV-1 …
it can also cause permanent brain damage and blindness. There is currently no HSV-1 …
[HTML][HTML] Broadly reactive human CD8 T cells that recognize an epitope conserved between VZV, HSV and EBV
Human herpesviruses are important causes of potentially severe chronic infections for which
T cells are believed to be necessary for control. In order to examine the role of virus-specific …
T cells are believed to be necessary for control. In order to examine the role of virus-specific …
Discovery of potential diagnostic and vaccine antigens in herpes simplex virus 1 and 2 by proteome-wide antibody profiling
M Kalantari-Dehaghi, S Chun, AA Chentoufi… - Journal of …, 2012 - Am Soc Microbiol
Routine serodiagnosis of herpes simplex virus (HSV) infections is currently performed using
recombinant glycoprotein G (gG) antigens from herpes simplex virus 1 (HSV-1) and HSV-2 …
recombinant glycoprotein G (gG) antigens from herpes simplex virus 1 (HSV-1) and HSV-2 …
[HTML][HTML] Discovering naturally processed antigenic determinants that confer protective T cell immunity
P Gilchuk, CT Spencer, SB Conant… - The Journal of …, 2013 - Am Soc Clin Investig
CD8+ T cells (TCD8) confer protective immunity against many infectious diseases,
suggesting that microbial TCD8 determinants are promising vaccine targets. Nevertheless …
suggesting that microbial TCD8 determinants are promising vaccine targets. Nevertheless …
Future of an 'Asymptomatic 'T-cell Epitope-Based Therapeutic Herpes Simplex Vaccine
X Dervillez, C Gottimukkala, KW Kabbara… - Future …, 2012 - Taylor & Francis
Considering the limited success of the recent herpes clinical vaccine trial, new vaccine
strategies are needed. Infections with HSV-1 and HSV-2 in the majority of men and women …
strategies are needed. Infections with HSV-1 and HSV-2 in the majority of men and women …
[HTML][HTML] Combinatorial herpes simplex vaccine strategies: from bedside to bench and back
AA Chentoufi, NR Dhanushkodi, R Srivastava… - Frontiers in …, 2022 - frontiersin.org
The development of vaccines against herpes simplex virus type 1 and type 2 (HSV1 and
HSV-2) is an important goal for global health. In this review we reexamined (i) the status of …
HSV-2) is an important goal for global health. In this review we reexamined (i) the status of …
[HTML][HTML] Identification of novel virus-specific antigens by CD4+ and CD8+ T cells from asymptomatic HSV-2 seropositive and seronegative donors
D Long, M Skoberne, TM Gierahn, S Larson, JA Price… - Virology, 2014 - Elsevier
Reactivation of latent herpes simplex virus 2 (HSV-2) infections can be characterized by
episodic recurrent genital lesions and/or viral shedding. We hypothesize that infected (HSV …
episodic recurrent genital lesions and/or viral shedding. We hypothesize that infected (HSV …
[HTML][HTML] Local CD4 and CD8 T-cell reactivity to HSV-1 antigens documents broad viral protein expression and immune competence in latently infected human …
M van Velzen, L Jing, ADME Osterhaus, A Sette… - PLoS …, 2013 - journals.plos.org
Herpes simplex virus type 1 (HSV-1) infection results in lifelong chronic infection of
trigeminal ganglion (TG) neurons, also referred to as neuronal HSV-1 latency, with periodic …
trigeminal ganglion (TG) neurons, also referred to as neuronal HSV-1 latency, with periodic …
[HTML][HTML] Diversity in CD8+ T Cell Function and Epitope Breadth Among Persons with Genital Herpes
KJ Laing, AS Magaret, DE Mueller, L Zhao… - Journal of clinical …, 2010 - Springer
CD8+ T cells are known to be important in clearing herpes simplex virus (HSV) infections.
However, investigating the specific antiviral mechanisms employed by HSV-2-specific T cell …
However, investigating the specific antiviral mechanisms employed by HSV-2-specific T cell …
[HTML][HTML] A rapid-response humoral vaccine platform exploiting pre-existing non-cognate populations of anti-vaccine or anti-viral CD4+ T helper cells to confirm B cell …
T Hills, PG Jakeman, RC Carlisle, P Klenerman… - PloS one, 2016 - journals.plos.org
The need for CD4+ T cell responses to arise de novo following vaccination can limit the
speed of B cell responses. Populations of pre-existing vaccine-induced or anti-viral CD4+ T …
speed of B cell responses. Populations of pre-existing vaccine-induced or anti-viral CD4+ T …