Lifelong persistent infection by herpesviruses depends on the balance between host
immune responses and viral immune evasion. CD4 T cells responding to antigens …

Highlights•Viruses thwart MHC-I presentation of viral antigens and hinder immune
responses.•Novel viral evasion proteins and mechanisms have been recently …

Herpesviruses stand out for their capacity to establish lifelong infections of
immunocompetent hosts, generally without causing overt symptoms. Herpesviruses are …

Immune evasion strategies are thought to contribute to successful persistence of viruses in
the infected immunocompetent host, delaying elimination of the infected cell long enough to …

Abstract HSV type 1 (HSV-1) has evolved numerous strategies for modifying immune
responses that protect against infection. Important targets of HSV-1 infection are the MHC …

The γ-herpesviruses, in contrast to the α-and β-herpesviruses, are not known to inhibit
antigen presentation to CD8+ cytotoxic T lymphocytes (CTLs) during lytic cycle replication …

Herpesviruses have evolved numerous strategies to evade detection by the immune system.
Notably, most of the herpesviruses interfere with viral antigen presentation to cytotoxic T …

Cytomegaloviruses (CMV), in common with other Herpesviruses, establish lifelong
persistence in their hosts. These highly host-specific viruses each encode viral genes that …

Herpesviruses, such as human and murine cytomegalovirus, possess an impressive array of
genes believed to assist in virus survival against the host immune response. In this review …

Major histocompatibility complex class I (MHCI) molecules are major targets of virus evasion
strategies because they introduce antigens from the biosynthesis pathway into the antigen …