Pregnane X receptor as a target for treatment of inflammatory bowel disorders
J Cheng, YM Shah, FJ Gonzalez - Trends in pharmacological sciences, 2012 - cell.com
Pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, has a
major role in the induction of genes involved in drug transport and metabolism. Recent …
major role in the induction of genes involved in drug transport and metabolism. Recent …
Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation
J Cheng, YM Shah, X Ma, X Pang, T Tanaka… - … of Pharmacology and …, 2010 - ASPET
Human pregnane X receptor (PXR) has been implicated in the pathogenesis of inflammatory
bowel disease (IBD). Rifaximin, a human PXR activator, is in clinical trials for treatment of …
bowel disease (IBD). Rifaximin, a human PXR activator, is in clinical trials for treatment of …
Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis
J Terc, A Hansen, L Alston, SA Hirota - European journal of pharmaceutical …, 2014 - Elsevier
The intestinal epithelial barrier plays a key role in the maintenance of homeostasis within the
gastrointestinal tract. Barrier dysfunction leading to increased epithelial permeability is …
gastrointestinal tract. Barrier dysfunction leading to increased epithelial permeability is …
Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease
J Glas, J Seiderer, D Fischer, B Tengler… - Inflammatory bowel …, 2011 - academic.oup.com
Background The pregnane X receptor (PXR/NR1I2) is an important regulator of xenobiotic
metabolism and intestinal integrity. However, there are controversial studies on the role of …
metabolism and intestinal integrity. However, there are controversial studies on the role of …
Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-κB target gene expression
YM Shah, X Ma, K Morimura, I Kim… - American Journal of …, 2007 - journals.physiology.org
Pregnane X receptor (PXR) expression was shown to be protective in inflammatory bowel
disease (IBD). However, the mechanism by which PXR provides protection remains unclear …
disease (IBD). However, the mechanism by which PXR provides protection remains unclear …
Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells
A Mencarelli, M Migliorati, M Barbanti, S Cipriani… - Biochemical …, 2010 - Elsevier
The pregnane-X-receptor (PXR) is master gene overseeing detoxification of wide number of
xenobiotics and is critical for maintenance of intestinal integrity. The intestinal expression of …
xenobiotics and is critical for maintenance of intestinal integrity. The intestinal expression of …
[HTML][HTML] Pregnane X receptor activation constrains mucosal NF-κB activity in active inflammatory bowel disease
JJ Deuring, M Li, W Cao, S Chen, W Wang, C de Haar… - PLoS …, 2019 - journals.plos.org
Background The Pregnane X Receptor (PXR) is a principal signal transducer in mucosal
responses to xenobiotic stress. It is well-recognized that inflammatory bowel disease is …
responses to xenobiotic stress. It is well-recognized that inflammatory bowel disease is …
Pregnane X receptor activation attenuates inflammation-associated intestinal epithelial barrier dysfunction by inhibiting cytokine-induced myosin light-chain kinase …
A Garg, A Zhao, SL Erickson, S Mukherjee… - … of Pharmacology and …, 2016 - ASPET
The inflammatory bowel diseases (IBDs) are chronic inflammatory disorders with a complex
etiology. IBD is thought to arise in genetically susceptible individuals in the context of …
etiology. IBD is thought to arise in genetically susceptible individuals in the context of …
Rifaximin is a gut-specific human pregnane X receptor activator
Rifaximin, a rifamycin analog approved for the treatment of travelers' diarrhea, is also
beneficial in the treatment of multiple chronic gastrointestinal disorders. However, the …
beneficial in the treatment of multiple chronic gastrointestinal disorders. However, the …
The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease
MM Dring, CA Goulding, VI Trimble, D Keegan… - Gastroenterology, 2006 - Elsevier
Background & Aims: The pregnane X receptor (PXR) regulates an array of genes involved in
the response to xenobiotics. Evidence from several studies suggests that xenobiotic …
the response to xenobiotics. Evidence from several studies suggests that xenobiotic …