During the last decades Ca 2+ has been found to play a crucial role in cardiac arrhythmias
associated with heart failure and a number of congenital arrhythmia syndromes. Recent …

During atrial fibrillation (AF) intracellular Ca2+ signaling in atrial myocytes changes
substantially. This 'remodeled'intracellular Ca2+ homeostasis plays an important role in the …

The transient elevation of intracellular Ca2+([Ca2+] i) with each heartbeat underlies the
activation of contraction and contributes to diverse regulatory features of cellular and …

Myocardial calcium signalling is a vital component of the normal physiological function of the
heart. Key amongst the many roles calcium plays is its use as the primary signalling …

Atrial fibrillation (AF) is the most prevalent sustained arrhythmia. As the most important risk
factor for embolic stroke, AF is associated with a high morbidity and mortality. Despite …

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and its prevalence is
increasing with the ageing of the population. Presently available treatment options are far …

Background: Chronic atrial fibrillation (cAF) is associated with abnormal atrial Ca2+
signalling, causing remodeling, contractile dysfunction and triggered activity. The poorly …

Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …

Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia in the clinical
setting. It is associated with substantial cardiovascular morbidity and mortality. Recent …

Triggered activity in cardiac muscle and intracellular Ca2+ have been linked in the past.
However, today not only are there a number of cellular proteins that show clear Ca2+ …