T cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy
driven mainly by oncogenic activation of NOTCH1 signaling. In this study we report the …

Reactive oxygen species (ROS), a byproduct of cellular metabolism, damage intracellular
macromolecules and, when present in excess, can promote normal hematopoietic stem cell …

T-cell acute lymphoblastic leukaemia (T-ALL) is a blood malignancy afflicting mainly
children and adolescents. T-ALL patients present at diagnosis with increased white cell …

The main oncogenic driver in T-lymphoblastic leukemia is NOTCH1, which activates genes
by forming chromatin-associated Notch transcription complexes. Gamma-secretase-inhibitor …

Notch1 regulates gene expression by associating with the DNA-binding factor RBPJ and is
oncogenic in murine and human T-cell progenitors. Using ChIP-Seq, we find that in human …

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal
overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non …

Very rare cases of human T cell acute lymphoblastic leukemia (T-ALL) harbor chromosomal
translocations that involve NOTCH1, a gene encoding a transmembrane receptor that …

Efforts to identify and annotate cancer driver genetic lesions have been focused primarily on
the analysis of protein-coding genes; however, most genetic abnormalities found in human …

The polycomb repressive complex 2 (PRC2) exerts oncogenic effects in many tumour types.
However, loss-of-function mutations in PRC2 components occur in a subset of …

T-cell acute lymphoblastic leukemia (T-ALL), unlike other ALL types, is only infrequently
associated with chromosomal aberrations, but it was recently shown that most individuals …